Protocadherin-12

UniProt data

UniProt name: PCD12_HUMAN (Q9NPG4)

Gene name: PCDH12; ORFNames=UNQ395/PRO731

Organism: Homo sapiens (Human).

Function: Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane; Single-pass type I membrane protein. Cell junction.

Transmembrane domains:

  1. 719-739, 21 AA, Helical. {ECO:0000255}.

Sequence: 1184 AA

10 20 30 40 50 60 MMQLLQLLLG LLGPGGYLFL LGDCQEVTTL TVKYQVSEEV PSGTVIGKLS QELGREERRR 70 80 90 100 110 120 QAGAAFQVLQ LPQALPIQVD SEEGLLSTGR RLDREQLCRQ WDPCLVSFDV LATGDLALIH 130 140 150 160 170 180 VEIQVLDIND HQPRFPKGEQ ELEISESASL RTRIPLDRAL DPDTGPNTLH TYTLSPSEHF 190 200 210 220 230 240 ALDVIVGPDE TKHAELIVVK ELDREIHSFF DLVLTAYDNG NPPKSGTSLV KVNVLDSNDN 250 260 270 280 290 300 SPAFAESSLA LEIQEDAAPG TLLIKLTATD PDQGPNGEVE FFLSKHMPPE VLDTFSIDAK 310 320 330 340 350 360 TGQVILRRPL DYEKNPAYEV DVQARDLGPN PIPAHCKVLI KVLDVNDNIP SIHVTWASQP 370 380 390 400 410 420 SLVSEALPKD SFIALVMADD LDSGHNGLVH CWLSQELGHF RLKRTNGNTY MLLTNATLDR 430 440 450 460 470 480 EQWPKYTLTL LAQDQGLQPL SAKKQLSIQI SDINDNAPVF EKSRYEVSTR ENNLPSLHLI 490 500 510 520 530 540 TIKAHDADLG INGKVSYRIQ DSPVAHLVAI DSNTGEVTAQ RSLNYEEMAG FEFQVIAEDS 550 560 570 580 590 600 GQPMLASSVS VWVSLLDAND NAPEVVQPVL SDGKASLSVL VNASTGHLLV PIETPNGLGP 610 620 630 640 650 660 AGTDTPPLAT HSSRPFLLTT IVARDADSGA NGEPLYSIRS GNEAHLFILN PHTGQLFVNV 670 680 690 700 710 720 TNASSLIGSE WELEIVVEDQ GSPPLQTRAL LRVMFVTSVD HLRDSARKPG ALSMSMLTVI 730 740 750 760 770 780 CLAVLLGIFG LILALFMSIC RTEKKDNRAY NCREAESTYR QQPKRPQKHI QKADIHLVPV 790 800 810 820 830 840 LRGQAGEPCE VGQSHKDVDK EAMMEAGWDP CLQAPFHLTP TLYRTLRNQG NQGAPAESRE 850 860 870 880 890 900 VLQDTVNLLF NHPRQRNASR ENLNLPEPQP ATGQPRSRPL KVAGSPTGRL AGDQGSEEAP 910 920 930 940 950 960 QRPPASSATL RRQRHLNGKV SPEKESGPRQ ILRSLVRLSV AAFAERNPVE ELTVDSPPVQ 970 980 990 1000 1010 1020 QISQLLSLLH QGQFQPKPNH RGNKYLAKPG GSRSAIPDTD GPSARAGGQT DPEQEEGPLD 1030 1040 1050 1060 1070 1080 PEEDLSVKQL LEEELSSLLD PSTGLALDRL SAPDPAWMAR LSLPLTTNYR DNVISPDAAA 1090 1100 1110 1120 1130 1140 TEEPRTFQTF GKAEAPELSP TGTRLASTFV SEMSSLLEML LEQRSSMPVE AASEALRRLS 1150 1160 1170 1180 VCGRTLSLDL ATSAASGMKV QGDPGGKTGT EGKSRGSSSS SRCL

CATM prediction

The sequence of PCD12_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      720       730       740
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 MLTVICLAVLLGIFGLILALFMSICRT 7.3 -51.1° 2.4 44.8 -12.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 727, GLY, HA2 A, 726, LEU, O 3.48Å
B, 730, GLY, HA1 A, 727, GLY, O 3.28Å
A, 727, GLY, HA2 B, 726, LEU, O 3.48Å
A, 730, GLY, HA1 B, 727, GLY, O 3.28Å