Triggering receptor expressed on myeloid cells 1

UniProt data

UniProt name: TREM1_HUMAN (Q9NP99)

Gene name: TREM1

Organism: Homo sapiens (Human).

Function: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. {ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:11323674}.

Subcellular location: Isoform 2: Secreted {ECO:0000305}.

Transmembrane domains:

  1. 206-226, 21 AA, Helical. {ECO:0000255}.

Sequence: 234 AA

10 20 30 40 50 60 MRKTRLWGLL WMLFVSELRA ATKLTEEKYE LKEGQTLDVK CDYTLEKFAS SQKAWQIIRD 70 80 90 100 110 120 GEMPKTLACT ERPSKNSHPV QVGRIILEDY HDHGLLRVRM VNLQVEDSGL YQCVIYQPPK 130 140 150 160 170 180 EPHMLFDRIR LVVTKGFSGT PGSNENSTQN VYKIPPTTTK ALCPLYTSPR TVTQAPPKST 190 200 210 220 230 ADVSTPDSEI NLTNVTDIIR VPVFNIVILL AGGFLSKSLV FSVLFAVTLR SFVP

CATM prediction

The sequence of TREM1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         210       220       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 VFNIVILLAGGFLSKSLVFSVLFAVTL 7.2 -48.9° 2.8 31.6 -38.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 212, GLY, HA1 A, 209, LEU, O 3.02Å
B, 213, GLY, HA2 A, 212, GLY, O 3.16Å
B, 216, SER, HG1 A, 213, GLY, O 2.32Å
B, 217, LYS, HZ3 A, 216, SER, OG 2.01Å
A, 212, GLY, HA1 B, 209, LEU, O 3.02Å
A, 213, GLY, HA2 B, 212, GLY, O 3.16Å
A, 216, SER, HG1 B, 213, GLY, O 2.32Å
A, 217, LYS, HZ3 B, 216, SER, OG 2.01Å