UniProt data
UniProt name: TNR12_HUMAN (Q9NP84)
Gene name: TNFRSF12A; Synonyms=FN14
Organism: Homo sapiens (Human).
Function: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. {ECO:0000269|PubMed:11728344}.
Subcellular location: Membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 81-101, 21 AA, Helical. {ECO:0000255}.
Sequence: 129 AA
CATM prediction
The sequence of TNR12_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 80 90 100 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | LWAILGGALSLTFVLGLLSGFLVWRRC | 6.8 | -47.9° | 0.5 | 47.0 | -25.9 |
| Model 2 | LWAILGGALSLTFVLGLLSGFLVWRRC | 6.8 | -43.0° | 3.0 | 34.8 | -22.0 |
| Model 3 | LWAILGGALSLTFVLGLLSGFLVWRRC | 7.0 | -49.0° | 2.9 | 32.0 | -13.0 |
| Prolines* | LWPILGGALSLTFVLGLLSGFLVWRRC |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 90, PHE, HA | A, 89, THR, O | 3.49Å |
| B, 93, GLY, HA1 | A, 90, PHE, O | 2.92Å |
| B, 94, LEU, HA | A, 93, GLY, O | 2.85Å |
| A, 90, PHE, HA | B, 89, THR, O | 3.49Å |
| A, 93, GLY, HA1 | B, 90, PHE, O | 2.92Å |
| A, 94, LEU, HA | B, 93, GLY, O | 2.85Å |
