HERV-H_2q24.3 provirus ancestral Env polyprotein

UniProt data

UniProt name: ENH1_HUMAN (Q9N2K0)

Gene name: %GENE_NAME%

Organism: Homo sapiens (Human).

Function: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.

Subcellular location: Transmembrane protein: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 524-544, 21 AA, Helical. {ECO:0000255}.

Sequence: 584 AA

10 20 30 40 50 60 MIFAGKAPSN TSTLMKFYSL LLYSLLFSFP FLCHPLPLPS YLHHTINLTH SLLAASNPSL 70 80 90 100 110 120 VNNCWLCISL SSSAYTAVPA VQTDWATSPI SLHLRTSFNS PHLYPPEELI YFLDRSSKTS 130 140 150 160 170 180 PDISHQQAAA LLRTYLKNLS PYINSTPPIF GPLTTQTTIP VAAPLCISWQ RPTGIPLGNL 190 200 210 220 230 240 SPSRCSFTLH LRSPTTNINE TIGAFQLHIT DKPSINTDKL KNISSNYCLG RHLPCISLHP 250 260 270 280 290 300 WLSSPCSSDS PPRPSSCLLI PSPENNSERL LVDTRRFLIH HENRTFPSTQ LPHQSPLQPL 310 320 330 340 350 360 TAAALAGSLG VWVQDTPFST PSHLFTLHLQ FCLAQGLFFL CGSSTYMCLP ANWTGTCTLV 370 380 390 400 410 420 FLTPKIQFAN GTEELPVPLM TPTQQKRVIP LIPLMVGLGL SASTVALGTG IAGISTSVMT 430 440 450 460 470 480 FRSLSNDFSA SITDISQTLS VLQAQVDSLA AVVLQNRRGL DLLTAEKGGL CIFLNEECCF 490 500 510 520 530 540 YLNQSGLVYD NIKKLKDRAQ KLANQASNYA EPPWALSNWM SWVLPIVSPL IPIFLLLLFG 550 560 570 580 PCIFRLVSQF IQNRIQAITN HSIRQMFLLT SPQYHPLPQD LPSA

CATM prediction

The sequence of ENH1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           530       540     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 SWVLAIVSALIAIFLLLLFGACIFRLV 6.9 -54.9° 1.5 44.8 -28.5
Prolines* SWVLPIVSPLIPIFLLLLFGPCIFRLV          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 537, LEU, HA A, 536, LEU, O 3.46Å
B, 540, GLY, HA1 A, 537, LEU, O 2.91Å
B, 541, ALA, HA A, 540, GLY, O 3.42Å
A, 537, LEU, HA B, 536, LEU, O 3.46Å
A, 540, GLY, HA1 B, 537, LEU, O 2.91Å
A, 541, ALA, HA B, 540, GLY, O 3.42Å