HERV-H_2q24.1 provirus ancestral Env polyprotein

UniProt data

UniProt name: ENH3_HUMAN (Q9N2J8)

Gene name: %GENE_NAME%

Organism: Homo sapiens (Human).

Function: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.

Subcellular location: Transmembrane protein: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 516-536, 21 AA, Helical. {ECO:0000255}.

Sequence: 555 AA

10 20 30 40 50 60 MILAGRAPSN TSTLMKFYSL LLYSLLFSFP FLYHPLPLPS YLHHTINLTH SLPAASNPSL 70 80 90 100 110 120 ANNCWLCISL SSSAYIAVPT LQTDRATSPV SLHLRTSFNS PHLYPPEELI YFLDRSSKTS 130 140 150 160 170 180 PDISHQPAAA LLHIYLKNLS PYINSTPPIF GPLTTQTTIP VAAPLCISRQ RPTGIPLGNI 190 200 210 220 230 240 SPSRCSFTLH LQSPTTHVTE TIGVFQLHII DKPSINTDKL KNVSSNYCLG RHLPYISLHP 250 260 270 280 290 300 WLPSPCSSDS PPRPSSCLLT PSPQNNSERL LVDTQRFLIH HENRTSSSMQ LAHQSPLQPL 310 320 330 340 350 360 TAAALAGSLG VWVQDTPFST PSHPFSLHLQ FCLTQGLFFL CGSSTYMCLP ANWTGTCTLV 370 380 390 400 410 420 FLTPKIQFAN GTKELPVPLM TLTPQKRVIP LIPLMVGLGL SASTIALSTG IAGISTSVTT 430 440 450 460 470 480 FRSPSNDFSA SITDISQTLS VLQAQVDSLA AVVLQNRRGL GLSILLNEEC CFYLNQSGLV 490 500 510 520 530 540 YENIKKLKDR AQKLANQASN YAESPWALSN WMSWVLPILS PLIPIFLLLL FGPCIFHLVS 550 QFIQNRIQAI TNHSI

CATM prediction

The sequence of ENH3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         520       530       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 SWVLAILSALIAIFLLLLFGACIFHLV 6.9 -55.0° 1.5 44.8 -29.2
Prolines* SWVLPILSPLIPIFLLLLFGPCIFHLV          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 529, LEU, HA A, 528, LEU, O 3.50Å
B, 532, GLY, HA1 A, 529, LEU, O 2.94Å
B, 533, ALA, HA A, 532, GLY, O 3.45Å
A, 529, LEU, HA B, 528, LEU, O 3.50Å
A, 532, GLY, HA1 B, 529, LEU, O 2.94Å
A, 533, ALA, HA B, 532, GLY, O 3.45Å