Adipocyte plasma membrane-associated protein

UniProt data

UniProt name: APMAP_HUMAN (Q9HDC9)

Gene name: APMAP; Synonyms=C20orf3; ORFNames=UNQ1869/PRO4305

Organism: Homo sapiens (Human).

Function: Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation. {ECO:0000269|PubMed:18513186}.

Subcellular location: Membrane {ECO:0000269|PubMed:18513186}; Single-pass type II membrane protein {ECO:0000269|PubMed:18513186}.

Transmembrane domains:

  1. 41-61, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 416 AA

10 20 30 40 50 60 MSEADGLRQR RPLRPQVVTD DDGQAPEAKD GSSFSGRVFR VTFLMLAVSL TVPLLGAMML 70 80 90 100 110 120 LESPIDPQPL SFKEPPLLLG VLHPNTKLRQ AERLFENQLV GPESIAHIGD VMFTGTADGR 130 140 150 160 170 180 VVKLENGEIE TIARFGSGPC KTRDDEPVCG RPLGIRAGPN GTLFVADAYK GLFEVNPWKR 190 200 210 220 230 240 EVKLLLSSET PIEGKNMSFV NDLTVTQDGR KIYFTDSSSK WQRRDYLLLV MEGTDDGRLL 250 260 270 280 290 300 EYDTVTREVK VLLDQLRFPN GVQLSPAEDF VLVAETTMAR IRRVYVSGLM KGGADLFVEN 310 320 330 340 350 360 MPGFPDNIRP SSSGGYWVGM STIRPNPGFS MLDFLSERPW IKRMIFKLFS QETVMKFVPR 370 380 390 400 410 YSLVLELSDS GAFRRSLHDP DGLVATYISE VHEHDGHLYL GSFRSPFLCR LSLQAV

CATM prediction

The sequence of APMAP_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    40        50        60   
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 VFRVTFLMLAVSLTVALLGAMMLLESA 7.1 -53.2° 3.1 34.4 -0.7
Prolines* VFRVTFLMLAVSLTVPLLGAMMLLESP          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 53, ALA, HA A, 52, VAL, O 3.26Å
B, 56, GLY, HA1 A, 53, ALA, O 3.13Å
A, 53, ALA, HA B, 52, VAL, O 3.26Å
A, 56, GLY, HA1 B, 53, ALA, O 3.13Å