Neurexin-3-beta

UniProt data

UniProt name: NRX3B_HUMAN (Q9HDB5)

Gene name: NRXN3; Synonyms=KIAA0743

Organism: Homo sapiens (Human).

Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 563-583, 21 AA, Helical. {ECO:0000255}.

Sequence: 637 AA

10 20 30 40 50 60 MHLRIHARRS PPRRPAWTLG IWFLFWGCIV SSVWSSSNVA SSSSTSSSPG SHSQHEHHFH 70 80 90 100 110 120 GSKHHSVPIS IYRSPVSLRG GHAGATYIFG KSGGLILYTW PANDRPSTRS DRLAVGFSTT 130 140 150 160 170 180 VKDGILVRID SAPGLGDFLQ LHIEQGKIGV VFNIGTVDIS IKEERTPVND GKYHVVRFTR 190 200 210 220 230 240 NGGNATLQVD NWPVNEHYPT GRQLTIFNTQ AQIAIGGKDK GRLFQGQLSG LYYDGLKVLN 250 260 270 280 290 300 MAAENNPNIK INGSVRLVGE VPSILGTTQT TSMPPEMSTT VMETTTTMAT TTTRKNRSTA 310 320 330 340 350 360 SIQPTSDDLV SSAECSSDDE DFVECEPSTG GELVIPLLVE DPLATPPIAT RAPSITLPPT 370 380 390 400 410 420 FRPLLTIIET TKDSLSMTSE AGLPCLSDQG SDGCDDDGLV ISGYGSGETF DSNLPPTDDE 430 440 450 460 470 480 DFYTTFSLVT DKSLSTSIFE GGYKAHAPKW ESKDFRPNKV SETSRTTTTS LSPELIRFTA 490 500 510 520 530 540 SSSSGMVPKL PAGKMNNRDL KPQPDIVLLP LPTAYELDST KLKSPLITSP MFRNVPTANP 550 560 570 580 590 600 TEPGIRRVPG ASEVIRESSS TTGMVVGIVA AAALCILILL YAMYKYRNRD EGSYQVDETR 610 620 630 NYISNSAQSN GTLMKEKQQS SKSGHKKQKN KDREYYV

CATM prediction

The sequence of NRX3B_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  560       570       580    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 STTGMVVGIVAAAALCILILLYAMYKY 6.4 -47.1° 3.3 54.0 -30.2
Model 2 STTGMVVGIVAAAALCILILLYAMYKY 7.3 -27.0° 6.0 58.0 -24.2
Model 3 STTGMVVGIVAAAALCILILLYAMYKY 7.3 -37.0° 2.2 36.0 -19.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 564, MET, HA A, 563, GLY, O 2.42Å
B, 567, GLY, HA1 A, 564, MET, O 2.58Å
B, 568, ILE, HA A, 567, GLY, O 3.45Å
A, 564, MET, HA B, 563, GLY, O 2.42Å
A, 567, GLY, HA1 B, 564, MET, O 2.58Å
A, 568, ILE, HA B, 567, GLY, O 3.45Å