Receptor-type tyrosine-protein phosphatase H

UniProt data

UniProt name: PTPRH_HUMAN (Q9HD43)

Gene name: PTPRH; Synonyms=SAP1

Organism: Homo sapiens (Human).

Function: May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion- associated substrates and thus negatively regulating integrin- promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells. {ECO:0000269|PubMed:11278335, ECO:0000269|PubMed:12101188, ECO:0000269|PubMed:12837766, ECO:0000269|PubMed:15850787}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12879010}.

Transmembrane domains:

  1. 755-775, 21 AA, Helical. {ECO:0000255}.

Sequence: 1115 AA

10 20 30 40 50 60 MAGAGGGLGV WGNLVLLGLC SWTGARAPAP NPGRNLTVET QTTSSISLSW EVPDGLDSQN 70 80 90 100 110 120 SNYWVQCTGD GGTTETRNTT ATNVTVDGLG PGSLYTCSVW VEKDGVNSSV GTVTTATAPN 130 140 150 160 170 180 PVRNLRVEAQ TNSSIALTWE VPDGPDPQNS TYGVEYTGDG GRAGTRSTAH TNITVDGLEP 190 200 210 220 230 240 GCLYAFSMWV GKNGINSSRE TRNATTAHNP VRNLRVEAQT TSSISLSWEV PDGTDPQNST 250 260 270 280 290 300 YCVQCTGDGG RTETRNTTDT RVTVDGLGPG SLYTCSVWVE KDGVNSSVEI VTSATAPNPV 310 320 330 340 350 360 RNLTVEAQTN SSIALTWEVP DGPDPQNSTY GVEYTGDGGR AGTRSTAHTN ITVDRLEPGC 370 380 390 400 410 420 LYVFSVWVGK NGINSSRETR NATTAPNPVR NLHMETQTNS SIALCWEVPD GPYPQDYTYW 430 440 450 460 470 480 VEYTGDGGGT ETRNTTNTSV TAERLEPGTL YTFSVWAEKN GARGSRQNVS ISTVPNAVTS 490 500 510 520 530 540 LSKQDWTNST IALRWTAPQG PGQSSYSYWV SWVREGMTDP RTQSTSGTDI TLKELEAGSL 550 560 570 580 590 600 YHLTVWAERN EVRGYNSTLT AATAPNEVTD LQNETQTKNS VMLWWKAPGD PHSQLYVYWV 610 620 630 640 650 660 QWASKGHPRR GQDPQANWVN QTSRTNETWY KVEALEPGTL YNFTVWAERN DVASSTQSLC 670 680 690 700 710 720 ASTYPDTVTI TSCVSTSAGY GVNLIWSCPQ GGYEAFELEV GGQRGSQDRS SCGEAVSVLG 730 740 750 760 770 780 LGPARSYPAT ITTIWDGMKV VSHSVVCHTE SAGVIAGAFV GILLFLILVG LLIFFLKRRN 790 800 810 820 830 840 KKKQQKPELR DLVFSSPGDI PAEDFADHVR KNERDSNCGF ADKYQQLSLV GHSQSQMVAS 850 860 870 880 890 900 ASENNAKNRY RNVLPYDWSR VPLKPIHEEP GSDYINASFM PGLWSPQEFI ATQGPLPQTV 910 920 930 940 950 960 GDFWRLVWEQ QSHTLVMLTN CMEAGRVKCE HYWPLDSQPC THGHLRVTLV GEEVMENWTV 970 980 990 1000 1010 1020 RELLLLQVEE QKTLSVRQFH YQAWPDHGVP SSPDTLLAFW RMLRQWLDQT MEGGPPIVHC 1030 1040 1050 1060 1070 1080 SAGVGRTGTL IALDVLLRQL QSEGLLGPFS FVRKMRESRP LMVQTEAQYV FLHQCILRFL 1090 1100 1110 QQSAQAPAEK EVPYEDVENL IYENVAAIQA HKLEV

CATM prediction

The sequence of PTPRH_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          760       770      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 AGVIAGAFVGILLFLILVGLLIFFLKR 6.4 -51.8° 5.3 40.0 -21.2
Model 2 AGVIAGAFVGILLFLILVGLLIFFLKR 6.5 -35.0° 3.8 53.0 -12.8
Model 3 AGVIAGAFVGILLFLILVGLLIFFLKR 6.4 -42.0° 6.0 58.0 -2.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 758, ALA, HA A, 757, GLY, O 2.46Å
B, 758, ALA, HA A, 758, ALA, O 3.49Å
B, 761, GLY, HA1 A, 758, ALA, O 2.97Å
A, 758, ALA, HA B, 757, GLY, O 2.46Å
A, 758, ALA, HA B, 758, ALA, O 3.49Å
A, 761, GLY, HA1 B, 758, ALA, O 2.97Å