Leucine-rich repeat-containing protein 4C

UniProt data

UniProt name: LRC4C_HUMAN (Q9HCJ2)

Gene name: LRRC4C; Synonyms=KIAA1580, NGL1; ORFNames=UNQ292/PRO331

Organism: Homo sapiens (Human).

Function: May promote neurite outgrowth of developing thalamic neurons. {ECO:0000269|PubMed:14595443}.

Subcellular location: Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}; Single-pass type I membrane protein {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}.

Transmembrane domains:

  1. 528-548, 21 AA, Helical. {ECO:0000255}.

Sequence: 640 AA

10 20 30 40 50 60 MLNKMTLHPQ QIMIGPRFNR ALFDPLLVVL LALQLLVVAG LVRAQTCPSV CSCSNQFSKV 70 80 90 100 110 120 ICVRKNLREV PDGISTNTRL LNLHENQIQI IKVNSFKHLR HLEILQLSRN HIRTIEIGAF 130 140 150 160 170 180 NGLANLNTLE LFDNRLTTIP NGAFVYLSKL KELWLRNNPI ESIPSYAFNR IPSLRRLDLG 190 200 210 220 230 240 ELKRLSYISE GAFEGLSNLR YLNLAMCNLR EIPNLTPLIK LDELDLSGNH LSAIRPGSFQ 250 260 270 280 290 300 GLMHLQKLWM IQSQIQVIER NAFDNLQSLV EINLAHNNLT LLPHDLFTPL HHLERIHLHH 310 320 330 340 350 360 NPWNCNCDIL WLSWWIKDMA PSNTACCARC NTPPNLKGRY IGELDQNYFT CYAPVIVEPP 370 380 390 400 410 420 ADLNVTEGMA AELKCRASTS LTSVSWITPN GTVMTHGAYK VRIAVLSDGT LNFTNVTVQD 430 440 450 460 470 480 TGMYTCMVSN SVGNTTASAT LNVTAATTTP FSYFSTVTVE TMEPSQDEAR TTDNNVGPTP 490 500 510 520 530 540 VVDWETTNVT TSLTPQSTRS TEKTFTIPVT DINSGIPGID EVMKTTKIII GCFVAITLMA 550 560 570 580 590 600 AVMLVIFYKM RKQHHRQNHH APTRTVEIIN VDDEITGDTP MESHLPMPAI EHEHLNHYNS 610 620 630 YKSPFNHTTT VNTINSIHSS VHEPLLIRMN SKDNVQETQI

CATM prediction

The sequence of LRC4C_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       530       540       55
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 TTKIIIGCFVAITLMAAVMLVIFYKMR 7.0 -49.0° 1.8 45.1 -27.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 531, GLY, HA1 A, 528, ILE, O 2.96Å
B, 532, CYS, HA A, 531, GLY, O 3.22Å
A, 531, GLY, HA1 B, 528, ILE, O 2.96Å
A, 532, CYS, HA B, 531, GLY, O 3.22Å