Leucine-rich repeat-containing protein 4

UniProt data

UniProt name: LRRC4_HUMAN (Q9HBW1)

Gene name: LRRC4; Synonyms=BAG; ORFNames=NAG14, UNQ554/PRO1111

Organism: Homo sapiens (Human).

Function: Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity). {ECO:0000250}.

Subcellular location: Membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Note=LRRC4 and DLG4 are interdependent for synaptic localization. {ECO:0000250}.

Transmembrane domains:

  1. 528-548, 21 AA, Helical. {ECO:0000255}.

Sequence: 653 AA

10 20 30 40 50 60 MKLLWQVTVH HHTWNAILLP FVYLTAQVWI LCAAIAAAAS AGPQNCPSVC SCSNQFSKVV 70 80 90 100 110 120 CTRRGLSEVP QGIPSNTRYL NLMENNIQMI QADTFRHLHH LEVLQLGRNS IRQIEVGAFN 130 140 150 160 170 180 GLASLNTLEL FDNWLTVIPS GAFEYLSKLR ELWLRNNPIE SIPSYAFNRV PSLMRLDLGE 190 200 210 220 230 240 LKKLEYISEG AFEGLFNLKY LNLGMCNIKD MPNLTPLVGL EELEMSGNHF PEIRPGSFHG 250 260 270 280 290 300 LSSLKKLWVM NSQVSLIERN AFDGLASLVE LNLAHNNLSS LPHDLFTPLR YLVELHLHHN 310 320 330 340 350 360 PWNCDCDILW LAWWLREYIP TNSTCCGRCH APMHMRGRYL VEVDQASFQC SAPFIMDAPR 370 380 390 400 410 420 DLNISEGRMA ELKCRTPPMS SVKWLLPNGT VLSHASRHPR ISVLNDGTLN FSHVLLSDTG 430 440 450 460 470 480 VYTCMVTNVA GNSNASAYLN VSTAELNTSN YSFFTTVTVE TTEISPEDTT RKYKPVPTTS 490 500 510 520 530 540 TGYQPAYTTS TTVLIQTTRV PKQVAVPATD TTDKMQTSLD EVMKTTKIII GCFVAVTLLA 550 560 570 580 590 600 AAMLIVFYKL RKRHQQRSTV TAARTVEIIQ VDEDIPAATS AAATAAPSGV SGEGAVVLPT 610 620 630 640 650 IHDHINYNTY KPAHGAHWTE NSLGNSLHPT VTTISEPYII QTHTKDKVQE TQI

CATM prediction

The sequence of LRRC4_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       530       540       55
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 TTKIIIGCFVAVTLLAAAMLIVFYKLR 7.0 -50.0° 2.9 47.0 -20.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 531, GLY, HA1 A, 528, ILE, O 2.97Å
A, 531, GLY, HA1 B, 528, ILE, O 2.97Å