Cadherin-related family member 5 {ECO:0000305}

UniProt data

UniProt name: CDHR5_HUMAN (Q9HBB8)

Gene name: CDHR5 {ECO:0000312|HGNC:HGNC:7521}

Organism: Homo sapiens (Human).

Function: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. {ECO:0000269|PubMed:24725409}.

Subcellular location: Apical cell membrane {ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:24725409}. Cell projection, microvillus membrane {ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:24725409}.

Transmembrane domains:

  1. 670-690, 21 AA, Helical. {ECO:0000255}.

Sequence: 845 AA

10 20 30 40 50 60 MGSWALLWPP LLFTGLLVRP PGTMAQAQYC SVNKDIFEVE ENTNVTEPLV DIHVPEGQEV 70 80 90 100 110 120 TLGALSTPFA FRIQGNQLFL NVTPDYEEKS LLEAQLLCQS GGTLVTQLRV FVSVLDVNDN 130 140 150 160 170 180 APEFPFKTKE IRVEEDTKVN STVIPETQLQ AEDRDKDDIL FYTLQEMTAG ASDYFSLVSV 190 200 210 220 230 240 NRPALRLDRP LDFYERPNMT FWLLVRDTPG ENVEPSHTAT ATLVLNVVPA DLRPPWFLPC 250 260 270 280 290 300 TFSDGYVCIQ AQYHGAVPTG HILPSPLVLR PGPIYAEDGD RGINQPIIYS IFRGNVNGTF 310 320 330 340 350 360 IIHPDSGNLT VARSVPSPMT FLLLVKGQQA DLARYSVTQV TVEAVAAAGS PPRFPQRLYR 370 380 390 400 410 420 GTVARGAGAG VVVKDAAAPS QPLRIQAQDP EFSDLNSAIT YRITNHSHFR MEGEVVLTTT 430 440 450 460 470 480 TLAQAGAFYA EVEAHNTVTS GTATTVIEIQ VSEQEPPSTD VPPSPEAGGT TGPWTSTTSE 490 500 510 520 530 540 VPRPPEPSQG PSTTSSGGGT GPHPPSGTTL RPPTSSTPGG PPGAENSTSH QPATPGGDTA 550 560 570 580 590 600 QTPKPGTSQP MPPGVGTSTS HQPATPSGGT AQTPEPGTSQ PMPPSMGTST SHQPATPGGG 610 620 630 640 650 660 TAQTPEAGTS QPMPPGMGTS TSHQPTTPGG GTAQTPEPGT SQPMPLSKST PSSGGGPSED 670 680 690 700 710 720 KRFSVVDMAA LGGVLGALLL LALLGLAVLV HKHYGPRLKC CCGKAPEPQP QGFDNQAFLP 730 740 750 760 770 780 DHKANWAPVP SPTHDPKPAE APMPAEPAPP GPASPGGAPE PPAAARAGGS PTAVRSILTK 790 800 810 820 830 840 ERRPEGGYKA VWFGEDIGTE ADVVVLNAPT LDVDGASDSG SGDEGEGAGR GGGPYDAPGG DDSYI

CATM prediction

The sequence of CDHR5_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     670       680       690 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 DMAALGGVLGALLLLALLGLAVLVHKH 6.9 -23.0° 4.2 54.0 -15.1
Model 2 DMAALGGVLGALLLLALLGLAVLVHKH 6.4 -49.2° 3.9 37.9 -13.0
Model 3 DMAALGGVLGALLLLALLGLAVLVHKH 6.9 -38.0° 5.7 34.0 -12.2
Model 4 DMAALGGVLGALLLLALLGLAVLVHKH 7.2 -36.0° 4.3 48.0 -4.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session