Interleukin-1 receptor-like 2

UniProt data

UniProt name: ILRL2_HUMAN (Q9HB29)

Gene name: IL1RL2; Synonyms=IL1RRP2

Organism: Homo sapiens (Human).

Function: Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL- 23/IL-17/IL-22 pathway. {ECO:0000250|UniProtKB:Q9ERS7, ECO:0000269|PubMed:11466363}.

Subcellular location: Membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:24829417}.

Transmembrane domains:

  1. 336-356, 21 AA, Helical. {ECO:0000255}.

Sequence: 575 AA

10 20 30 40 50 60 MWSLLLCGLS IALPLSVTAD GCKDIFMKNE ILSASQPFAF NCTFPPITSG EVSVTWYKNS 70 80 90 100 110 120 SKIPVSKIIQ SRIHQDETWI LFLPMEWGDS GVYQCVIKGR DSCHRIHVNL TVFEKHWCDT 130 140 150 160 170 180 SIGGLPNLSD EYKQILHLGK DDSLTCHLHF PKSCVLGPIK WYKDCNEIKG ERFTVLETRL 190 200 210 220 230 240 LVSNVSAEDR GNYACQAILT HSGKQYEVLN GITVSITERA GYGGSVPKII YPKNHSIEVQ 250 260 270 280 290 300 LGTTLIVDCN VTDTKDNTNL RCWRVNNTLV DDYYDESKRI REGVETHVSF REHNLYTVNI 310 320 330 340 350 360 TFLEVKMEDY GLPFMCHAGV STAYIILQLP APDFRAYLIG GLIALVAVAV SVVYIYNIFK 370 380 390 400 410 420 IDIVLWYRSA FHSTETIVDG KLYDAYVLYP KPHKESQRHA VDALVLNILP EVLERQCGYK 430 440 450 460 470 480 LFIFGRDEFP GQAVANVIDE NVKLCRRLIV IVVPESLGFG LLKNLSEEQI AVYSALIQDG 490 500 510 520 530 540 MKVILIELEK IEDYTVMPES IQYIKQKHGA IRWHGDFTEQ SQCMKTKFWK TVRYHMPPRR 550 560 570 CRPFPPVQLL QHTPCYRTAG PELGSRRKKC TLTTG

CATM prediction

The sequence of ILRL2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         340       350       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 DFRAYLIGGLIALVAVAVSVVYIYNIF 6.5 -53.0° 1.9 45.4 -31.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 337, TYR, HA A, 336, ALA, O 2.98Å
B, 340, GLY, HA1 A, 337, TYR, O 2.42Å
B, 341, GLY, HA2 A, 340, GLY, O 2.84Å
A, 337, TYR, HA B, 336, ALA, O 2.98Å
A, 340, GLY, HA1 B, 337, TYR, O 2.42Å
A, 341, GLY, HA2 B, 340, GLY, O 2.84Å