Protein eva-1 homolog A

UniProt data

UniProt name: EVA1A_HUMAN (Q9H8M9)

Gene name: EVA1A; Synonyms=FAM176A, TMEM166; ORFNames=SP24

Organism: Homo sapiens (Human).

Function: Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis. {ECO:0000269|PubMed:17492404, ECO:0000269|PubMed:19029833}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17492404}; Single-pass membrane protein {ECO:0000269|PubMed:17492404}. Lysosome membrane {ECO:0000269|PubMed:17492404}; Single-pass membrane protein {ECO:0000269|PubMed:17492404}.

Transmembrane domains:

  1. 35-55, 21 AA, Helical. {ECO:0000255}.

Sequence: 152 AA

10 20 30 40 50 60 MRLPLSHSPE HVEMALLSNI LAAYSFVSEN PERAALYFVS GVCIGLVLTL AALVIRISCH 70 80 90 100 110 120 TDCRRRPGKK FLQDRESSSD SSDSEDGSED TVSDLSVRRH RRFERTLNKN VFTSAEELER 130 140 150 AQRLEERERI IREIWMNGQP EVPGTRSLNR YY

CATM prediction

The sequence of EVA1A_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          40        50       
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 ERAALYFVSGVCIGLVLTLAALVIRIS 7.3 -21.5° 4.7 37.0 -48.7
Model 2 ERAALYFVSGVCIGLVLTLAALVIRIS 6.4 -50.9° 4.8 56.7 -32.8
Model 3 ERAALYFVSGVCIGLVLTLAALVIRIS 7.4 -54.0° 2.8 51.2 -1.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 38, PHE, HA A, 37, TYR, O 3.04Å
B, 41, GLY, HA1 A, 38, PHE, O 3.46Å
B, 49, THR, HA A, 49, THR, OG1 3.12Å
A, 38, PHE, HA B, 37, TYR, O 3.04Å
A, 41, GLY, HA1 B, 38, PHE, O 3.46Å
A, 49, THR, HA B, 49, THR, OG1 3.00Å
A, 49, THR, HG1 B, 49, THR, OG1 2.06Å