Prostaglandin E synthase 2

UniProt data

UniProt name: PGES2_HUMAN (Q9H7Z7)

Gene name: PTGES2; Synonyms=C9orf15, PGES2

Organism: Homo sapiens (Human).

Function: Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2). {ECO:0000269|PubMed:12804604, ECO:0000269|PubMed:18198127}.

Subcellular location: Prostaglandin E synthase 2 truncated form: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12835322}. Note=Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region. {ECO:0000269|PubMed:12835322}.

Transmembrane domains:

  1. 58-74, 17 AA, Helical. {ECO:0000255}.

Sequence: 377 AA

10 20 30 40 50 60 MDPAARVVRA LWPGGCALAW RLGGRPQPLL PTQSRAGFAG AAGGPSPVAA ARKGSPRLLG 70 80 90 100 110 120 AAALALGGAL GLYHTARWHL RAQDLHAERS AAQLSLSSRL QLTLYQYKTC PFCSKVRAFL 130 140 150 160 170 180 DFHALPYQVV EVNPVRRAEI KFSSYRKVPI LVAQEGESSQ QLNDSSVIIS ALKTYLVSGQ 190 200 210 220 230 240 PLEEIITYYP AMKAVNEQGK EVTEFGNKYW LMLNEKEAQQ VYGGKEARTE EMKWRQWADD 250 260 270 280 290 300 WLVHLISPNV YRTPTEALAS FDYIVREGKF GAVEGAVAKY MGAAAMYLIS KRLKSRHRLQ 310 320 330 340 350 360 DNVREDLYEA ADKWVAAVGK DRPFMGGQKP NLADLAVYGV LRVMEGLDAF DDLMQHTHIQ 370 PWYLRVERAI TEASPAH

CATM prediction

The sequence of PGES2_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       60        70      
+    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 SARLLGAAALALGGALGLYHTAR 7.0 -26.0° 3.6 54.2 -29.3
Model 2 SARLLGAAALALGGALGLYHTAR 6.8 -54.0° 2.6 33.1 -6.2
Model 3 SARLLGAAALALGGALGLYHTAR 6.5 -44.4° 4.9 44.0 -4.1
Prolines* SPRLLGAAALALGGALGLYHTAR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 64, LEU, HA A, 63, ALA, O 2.79Å
B, 67, GLY, HA1 A, 64, LEU, O 3.40Å
A, 64, LEU, HA B, 63, ALA, O 2.79Å
A, 67, GLY, HA1 B, 64, LEU, O 3.40Å