V-type immunoglobulin domain-containing suppressor of T-cell activation {ECO:0000303|PubMed:24691993}

UniProt data

UniProt name: VISTA_HUMAN (Q9H7M9)

Gene name: C10orf54

Organism: Homo sapiens (Human).

Function: Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}; Single-pass type I membrane protein {ECO:0000255}.

Transmembrane domains:

  1. 195-215, 21 AA, Helical. {ECO:0000255}.

Sequence: 311 AA

10 20 30 40 50 60 MGVPTALEAG SWRWGSLLFA LFLAASLGPV AAFKVATPYS LYVCPEGQNV TLTCRLLGPV 70 80 90 100 110 120 DKGHDVTFYK TWYRSSRGEV QTCSERRPIR NLTFQDLHLH HGGHQAANTS HDLAQRHGLE 130 140 150 160 170 180 SASDHHGNFS ITMRNLTLLD SGLYCCLVVE IRHHHSEHRV HGAMELQVQT GKDAPSNCVV 190 200 210 220 230 240 YPSSSQDSEN ITAAALATGA CIVGILCLPL ILLLVYKQRQ AASNRRAQEL VRMDSNIQGI 250 260 270 280 290 300 ENPGFEASPP AQGIPEAKVR HPLSYVAQRQ PSESGRHLLS EPSTPLSPPG PGDVFFPSLD 310 PVPDSPNFEV I

CATM prediction

The sequence of VISTA_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          200       210      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 TAAALATGACIVGILCLALILLLVYKQ 7.4 -40.8° 3.5 37.7 -14.1
Prolines* TAAALATGACIVGILCLPLILLLVYKQ          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 196, LEU, HA A, 195, ALA, O 3.35Å
B, 199, GLY, HA1 A, 196, LEU, O 3.43Å
A, 196, LEU, HA B, 195, ALA, O 3.35Å
A, 199, GLY, HA1 B, 196, LEU, O 3.43Å