Leucine-rich repeat-containing protein 19

UniProt data

UniProt name: LRC19_HUMAN (Q9H756)

Gene name: LRRC19

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 271-291, 21 AA, Helical. {ECO:0000255}.

Sequence: 370 AA

10 20 30 40 50 60 MKVTGITILF WPLSMILLSD KIQSSKREVQ CNFTEKNYTL IPADIKKDVT ILDLSYNQIT 70 80 90 100 110 120 LNGTDTRVLQ TYFLLTELYL IENKVTILHN NGFGNLSSLE ILNICRNSIY VIQQGAFLGL 130 140 150 160 170 180 NKLKQLYLCQ NKIEQLNADV FVPLRSLKLL NLQGNLISYL DVPPLFHLEL ITLYGNLWNC 190 200 210 220 230 240 SCSLFNLQNW LNTSNVTLEN ENITMCSYPN SLQSYNIKTV PHKAECHSKF PSSVTEDLYI 250 260 270 280 290 300 HFQPISNSIF NSSSNNLTRN SEHEPLGKSW AFLVGVVVTV LTTSLLIFIA IKCPIWYNIL 310 320 330 340 350 360 LSYNHHRLEE HEAETYEDGF TGNPSSLSQI PETNSEETTV IFEQLHSFVV DDDGFIEDKY IDIHELCEEN

CATM prediction

The sequence of LRC19_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    270       280       290  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 KSWAFLVGVVVTVLTTSLLIFIAIKCA 7.5 -45.9° 2.7 47.2 -5.7
Prolines* KSWAFLVGVVVTVLTTSLLIFIAIKCP          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 272, PHE, HA A, 271, ALA, O 3.47Å
B, 275, GLY, HA1 A, 272, PHE, O 3.46Å
B, 276, VAL, HA A, 279, THR, OG1 2.61Å
A, 272, PHE, HA B, 271, ALA, O 3.47Å
A, 275, GLY, HA1 B, 272, PHE, O 3.46Å
A, 276, VAL, HA B, 279, THR, OG1 2.64Å