CXADR-like membrane protein

UniProt data

UniProt name: CLMP_HUMAN (Q9H6B4)

Gene name: CLMP; Synonyms=ACAM, ASAM; ORFNames=UNQ318/PRO363

Organism: Homo sapiens (Human).

Function: May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development. {ECO:0000269|PubMed:14573622, ECO:0000269|PubMed:15563274, ECO:0000269|PubMed:22155368}.

Subcellular location: Cell junction, tight junction {ECO:0000269|PubMed:14573622, ECO:0000269|PubMed:22155368}. Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 236-256, 21 AA, Helical. {ECO:0000255}.

Sequence: 373 AA

10 20 30 40 50 60 MSLLLLLLLV SYYVGTLGTH TEIKRVAEEK VTLPCHHQLG LPEKDTLDIE WLLTDNEGNQ 70 80 90 100 110 120 KVVITYSSRH VYNNLTEEQK GRVAFASNFL AGDASLQIEP LKPSDEGRYT CKVKNSGRYV 130 140 150 160 170 180 WSHVILKVLV RPSKPKCELE GELTEGSDLT LQCESSSGTE PIVYYWQRIR EKEGEDERLP 190 200 210 220 230 240 PKSRIDYNHP GRVLLQNLTM SYSGLYQCTA GNEAGKESCV VRVTVQYVQS IGMVAGAVTG 250 260 270 280 290 300 IVAGALLIFL LVWLLIRRKD KERYEEEERP NEIREDAEAP KARLVKPSSS SSGSRSSRSG 310 320 330 340 350 360 SSSTRSTANS ASRSQRTLST DAAPQPGLAT QAYSLVGPEV RGSEPKKVHH ANLTKAETTP 370 SMIPSQSRAF QTV

CATM prediction

The sequence of CLMP_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         240       250       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 MVAGAVTGIVAGALLIFLLVWLLIRRK 6.8 -28.1° 6.0 47.2 -38.5
Model 2 MVAGAVTGIVAGALLIFLLVWLLIRRK 6.8 -45.6° 4.7 37.5 -26.9
Model 3 MVAGAVTGIVAGALLIFLLVWLLIRRK 6.9 -54.9° 5.6 39.3 -18.2
Model 4 MVAGAVTGIVAGALLIFLLVWLLIRRK 7.3 -51.0° 3.3 47.8 -12.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 237, ALA, HA A, 236, GLY, O 2.59Å
B, 240, GLY, HA1 A, 237, ALA, O 3.37Å
A, 237, ALA, HA B, 236, GLY, O 2.59Å
A, 240, GLY, HA1 B, 237, ALA, O 3.37Å