SLIT and NTRK-like protein 6

UniProt data

UniProt name: SLIK6_HUMAN (Q9H5Y7)

Gene name: SLITRK6

Organism: Homo sapiens (Human).

Function: Regulator of neurite outgrowth required for normal hearing and vision. {ECO:0000269|PubMed:23543054}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:23543054, ECO:0000269|PubMed:23946138}; Single-pass type I membrane protein {ECO:0000269|PubMed:23543054, ECO:0000269|PubMed:23946138}.

Transmembrane domains:

  1. 609-629, 21 AA, Helical. {ECO:0000255}.

Sequence: 841 AA

10 20 30 40 50 60 MKLWIHLFYS SLLACISLHS QTPVLSSRGS CDSLCNCEEK DGTMLINCEA KGIKMVSEIS 70 80 90 100 110 120 VPPSRPFQLS LLNNGLTMLH TNDFSGLTNA ISIHLGFNNI ADIEIGAFNG LGLLKQLHIN 130 140 150 160 170 180 HNSLEILKED TFHGLENLEF LQADNNFITV IEPSAFSKLN RLKVLILNDN AIESLPPNIF 190 200 210 220 230 240 RFVPLTHLDL RGNQLQTLPY VGFLEHIGRI LDLQLEDNKW ACNCDLLQLK TWLENMPPQS 250 260 270 280 290 300 IIGDVVCNSP PFFKGSILSR LKKESICPTP PVYEEHEDPS GSLHLAATSS INDSRMSTKT 310 320 330 340 350 360 TSILKLPTKA PGLIPYITKP STQLPGPYCP IPCNCKVLSP SGLLIHCQER NIESLSDLRP 370 380 390 400 410 420 PPQNPRKLIL AGNIIHSLMK SDLVEYFTLE MLHLGNNRIE VLEEGSFMNL TRLQKLYLNG 430 440 450 460 470 480 NHLTKLSKGM FLGLHNLEYL YLEYNAIKEI LPGTFNPMPK LKVLYLNNNL LQVLPPHIFS 490 500 510 520 530 540 GVPLTKVNLK TNQFTHLPVS NILDDLDLLT QIDLEDNPWD CSCDLVGLQQ WIQKLSKNTV 550 560 570 580 590 600 TDDILCTSPG HLDKKELKAL NSEILCPGLV NNPSMPTQTS YLMVTTPATT TNTADTILRS 610 620 630 640 650 660 LTDAVPLSVL ILGLLIMFIT IVFCAAGIVV LVLHRRRRYK KKQVDEQMRD NSPVHLQYSM 670 680 690 700 710 720 YGHKTTHHTT ERPSASLYEQ HMVSPMVHVY RSPSFGPKHL EEEEERNEKE GSDAKHLQRS 730 740 750 760 770 780 LLEQENHSPL TGSNMKYKTT NQSTEFLSFQ DASSLYRNIL EKERELQQLG ITEYLRKNIA 790 800 810 820 830 840 QLQPDMEAHY PGAHEELKLM ETLMYSRPRK VLVEQTKNEY FELKANLHAE PDYLEVLEQQ T

CATM prediction

The sequence of SLIK6_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      610       620       630
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 ALSVLILGLLIMFITIVFCAAGIVVLV 7.4 -50.0° 2.8 47.2 -26.5
Prolines* PLSVLILGLLIMFITIVFCAAGIVVLV          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 610, LEU, HA A, 609, VAL, O 3.47Å
B, 613, GLY, HA1 A, 610, LEU, O 3.40Å
A, 610, LEU, HA B, 609, VAL, O 3.47Å
A, 613, GLY, HA1 B, 610, LEU, O 3.40Å