CUB domain-containing protein 1

UniProt data

UniProt name: CDCP1_HUMAN (Q9H5V8)

Gene name: CDCP1; Synonyms=TRASK; ORFNames=UNQ2486/PRO5773

Organism: Homo sapiens (Human).

Function: May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. {ECO:0000269|PubMed:11466621, ECO:0000269|PubMed:12799299, ECO:0000269|PubMed:15153610, ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:16404722, ECO:0000269|PubMed:8647901}.

Subcellular location: Isoform 3: Secreted.

Transmembrane domains:

  1. 668-688, 21 AA, Helical. {ECO:0000255}.

Sequence: 836 AA

10 20 30 40 50 60 MAGLNCGVSI ALLGVLLLGA ARLPRGAEAF EIALPRESNI TVLIKLGTPT LLAKPCYIVI 70 80 90 100 110 120 SKRHITMLSI KSGERIVFTF SCQSPENHFV IEIQKNIDCM SGPCPFGEVQ LQPSTSLLPT 130 140 150 160 170 180 LNRTFIWDVK AHKSIGLELQ FSIPRLRQIG PGESCPDGVT HSISGRIDAT VVRIGTFCSN 190 200 210 220 230 240 GTVSRIKMQE GVKMALHLPW FHPRNVSGFS IANRSSIKRL CIIESVFEGE GSATLMSANY 250 260 270 280 290 300 PEGFPEDELM TWQFVVPAHL RASVSFLNFN LSNCERKEER VEYYIPGSTT NPEVFKLEDK 310 320 330 340 350 360 QPGNMAGNFN LSLQGCDQDA QSPGILRLQF QVLVQHPQNE SNKIYVVDLS NERAMSLTIE 370 380 390 400 410 420 PRPVKQSRKF VPGCFVCLES RTCSSNLTLT SGSKHKISFL CDDLTRLWMN VEKTISCTDH 430 440 450 460 470 480 RYCQRKSYSL QVPSDILHLP VELHDFSWKL LVPKDRLSLV LVPAQKLQQH THEKPCNTSF 490 500 510 520 530 540 SYLVASAIPS QDLYFGSFCP GGSIKQIQVK QNISVTLRTF APSFQQEASR QGLTVSFIPY 550 560 570 580 590 600 FKEEGVFTVT PDTKSKVYLR TPNWDRGLPS LTSVSWNISV PRDQVACLTF FKERSGVVCQ 610 620 630 640 650 660 TGRAFMIIQE QRTRAEEIFS LDEDVLPKPS FHHHSFWVNI SNCSPTSGKQ LDLLFSVTLT 670 680 690 700 710 720 PRTVDLTVIL IAAVGGGVLL LSALGLIICC VKKKKKKTNK GPAVGIYNDN INTEMPRQPK 730 740 750 760 770 780 KFQKGRKDND SHVYAVIEDT MVYGHLLQDS SGSFLQPEVD TYRPFQGTMG VCPPSPPTIC 790 800 810 820 830 SRAPTAKLAT EEPPPRSPPE SESEPYTFSH PNNGDVSSKD TDIPLLNTQE PMEPAE

CATM prediction

The sequence of CDCP1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       670       680       69
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 DLTVILIAAVGGGVLLLSALGLIICCV 6.5 -54.3° 3.6 35.0 -29.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 673, ALA, HA A, 672, ALA, O 2.52Å
B, 673, ALA, HA A, 673, ALA, O 3.47Å
B, 676, GLY, HA1 A, 673, ALA, O 2.52Å
A, 673, ALA, HA B, 672, ALA, O 2.52Å
A, 673, ALA, HA B, 673, ALA, O 3.47Å
A, 676, GLY, HA1 B, 673, ALA, O 2.52Å