Alpha-1,3/1,6-mannosyltransferase ALG2

UniProt data

UniProt name: ALG2_HUMAN (Q9H553)

Gene name: ALG2; ORFNames=UNQ666/PRO1298

Organism: Homo sapiens (Human).

Function: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate. {ECO:0000269|PubMed:12684507}.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 85-105, 21 AA, Helical. {ECO:0000255}.

Sequence: 416 AA

10 20 30 40 50 60 MAEEQGRERD SVPKPSVLFL HPDLGVGGAE RLVLDAALAL QARGCSVKIW TAHYDPGHCF 70 80 90 100 110 120 AESRELPVRC AGDWLPRGLG WGGRGAAVCA YVRMVFLALY VLFLADEEFD VVVCDQVSAC 130 140 150 160 170 180 IPVFRLARRR KKILFYCHFP DLLLTKRDSF LKRLYRAPID WIEEYTTGMA DCILVNSQFT 190 200 210 220 230 240 AAVFKETFKS LSHIDPDVLY PSLNVTSFDS VVPEKLDDLV PKGKKFLLLS INRYERKKNL 250 260 270 280 290 300 TLALEALVQL RGRLTSQDWE RVHLIVAGGY DERVLENVEH YQELKKMVQQ SDLGQYVTFL 310 320 330 340 350 360 RSFSDKQKIS LLHSCTCVLY TPSNEHFGIV PLEAMYMQCP VIAVNSGGPL ESIDHSVTGF 370 380 390 400 410 LCEPDPVHFS EAIEKFIREP SLKATMGLAG RARVKEKFSP EAFTEQLYRY VTKLLV

CATM prediction

The sequence of ALG2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          90        100      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 GGRGAAVCAYVRMVFLALYVLFLADEE 7.1 -40.2° 2.7 33.9 -0.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 90, ALA, HA A, 91, TYR, OH 3.39Å
B, 93, ARG, HE A, 91, TYR, OH 2.14Å
A, 90, ALA, HA B, 91, TYR, OH 3.10Å
A, 93, ARG, HH12 B, 91, TYR, OH 2.35Å