Leucine-rich repeat neuronal protein 3

UniProt data

UniProt name: LRRN3_HUMAN (Q9H3W5)

Gene name: LRRN3; ORFNames=Nbla10363, UNQ194/PRO220

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 629-649, 21 AA, Helical. {ECO:0000255}.

Sequence: 708 AA

10 20 30 40 50 60 MKDMPLRIHV LLGLAITTLV QAVDKKVDCP RLCTCEIRPW FTPRSIYMEA STVDCNDLGL 70 80 90 100 110 120 LTFPARLPAN TQILLLQTNN IAKIEYSTDF PVNLTGLDLS QNNLSSVTNI NVKKMPQLLS 130 140 150 160 170 180 VYLEENKLTE LPEKCLSELS NLQELYINHN LLSTISPGAF IGLHNLLRLH LNSNRLQMIN 190 200 210 220 230 240 SKWFDALPNL EILMIGENPI IRIKDMNFKP LINLRSLVIA GINLTEIPDN ALVGLENLES 250 260 270 280 290 300 ISFYDNRLIK VPHVALQKVV NLKFLDLNKN PINRIRRGDF SNMLHLKELG INNMPELISI 310 320 330 340 350 360 DSLAVDNLPD LRKIEATNNP RLSYIHPNAF FRLPKLESLM LNSNALSALY HGTIESLPNL 370 380 390 400 410 420 KEISIHSNPI RCDCVIRWMN MNKTNIRFME PDSLFCVDPP EFQGQNVRQV HFRDMMEICL 430 440 450 460 470 480 PLIAPESFPS NLNVEAGSYV SFHCRATAEP QPEIYWITPS GQKLLPNTLT DKFYVHSEGT 490 500 510 520 530 540 LDINGVTPKE GGLYTCIATN LVGADLKSVM IKVDGSFPQD NNGSLNIKIR DIQANSVLVS 550 560 570 580 590 600 WKASSKILKS SVKWTAFVKT ENSHAAQSAR IPSDVKVYNL THLNPSTEYK ICIDIPTIYQ 610 620 630 640 650 660 KNRKKCVNVT TKGLHPDQKE YEKNNTTTLM ACLGGLLGII GVICLISCLS PEMNCDGGHS 670 680 690 700 YVRNYLQKPT FALGELYPPL INLWEAGKEK STSLKVKATV IGLPTNMS

CATM prediction

The sequence of LRRN3_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      630       640       650
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 TTTLMACLGGLLGIIGVICLISCLSAE 6.7 +47.9° 1.9 0.2 -15.6
Model 2 TTTLMACLGGLLGIIGVICLISCLSAE 6.3 -51.0° 6.0 45.3 -15.5
Prolines* TTTLMACLGGLLGIIGVICLISCLSPE          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 635, GLY, HA2 A, 634, GLY, O 3.49Å
B, 638, GLY, HA1 A, 634, GLY, O 3.30Å
B, 638, GLY, HA2 A, 637, LEU, O 3.07Å
A, 635, GLY, HA2 B, 634, GLY, O 3.49Å
A, 638, GLY, HA1 B, 634, GLY, O 3.30Å
A, 638, GLY, HA2 B, 637, LEU, O 3.07Å