UniProt data
UniProt name: SEM6B_HUMAN (Q9H3T3)
Gene name: SEMA6B; Synonyms=SEMAN, SEMAZ; ORFNames=UNQ1907/PRO4353
Organism: Homo sapiens (Human).
Function: May play a role in both peripheral and central nervous system development. {ECO:0000250}.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 604-624, 21 AA, Helical. {ECO:0000255}.
Sequence: 888 AA
10 20 30 40 50 60
MQTPRASPPR PALLLLLLLL GGAHGLFPEE PPPLSVAPRD YLNHYPVFVG SGPGRLTPAE
70 80 90 100 110 120
GADDLNIQRV LRVNRTLFIG DRDNLYRVEL EPPTSTELRY QRKLTWRSNP SDINVCRMKG
130 140 150 160 170 180
KQEGECRNFV KVLLLRDEST LFVCGSNAFN PVCANYSIDT LQPVGDNISG MARCPYDPKH
190 200 210 220 230 240
ANVALFSDGM LFTATVTDFL AIDAVIYRSL GDRPTLRTVK HDSKWFKEPY FVHAVEWGSH
250 260 270 280 290 300
VYFFFREIAM EFNYLEKVVV SRVARVCKND VGGSPRVLEK QWTSFLKARL NCSVPGDSHF
310 320 330 340 350 360
YFNVLQAVTG VVSLGGRPVV LAVFSTPSNS IPGSAVCAFD LTQVAAVFEG RFREQKSPES
370 380 390 400 410 420
IWTPVPEDQV PRPRPGCCAA PGMQYNASSA LPDDILNFVK THPLMDEAVP SLGHAPWILR
430 440 450 460 470 480
TLMRHQLTRV AVDVGAGPWG NQTVVFLGSE AGTVLKFLVR PNASTSGTSG LSVFLEEFET
490 500 510 520 530 540
YRPDRCGRPG GGETGQRLLS LELDAASGGL LAAFPRCVVR VPVARCQQYS GCMKNCIGSQ
550 560 570 580 590 600
DPYCGWAPDG SCIFLSPGTR AAFEQDVSGA STSGLGDCTG LLRASLSEDR AGLVSVNLLV
610 620 630 640 650 660
TSSVAAFVVG AVVSGFSVGW FVGLRERREL ARRKDKEAIL AHGAGEAVLS VSRLGERRAQ
670 680 690 700 710 720
GPGGRGGGGG GGAGVPPEAL LAPLMQNGWA KATLLQGGPH DLDSGLLPTP EQTPLPQKRL
730 740 750 760 770 780
PTPHPHPHAL GPRAWDHGHP LLPASASSSL LLLAPARAPE QPPAPGEPTP DGRLYAARPG
790 800 810 820 830 840
RASHGDFPLT PHASPDRRRV VSAPTGPLDP ASAADGLPRP WSPPPTGSLR RPLGPHAPPA
850 860 870 880
ATLRRTHTFN SGEARPGDRH RGCHARPGTD LAHLLPYGGA DRTAPPVP
CATM prediction
The sequence of SEM6B_HUMAN returned 5 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 610 620 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | TSSVAAFVVGAVVSGFSVGWFVGLRER | 6.4 | -38.0° | 4.5 | 57.0 | -35.4 |
| Model 2 | TSSVAAFVVGAVVSGFSVGWFVGLRER | 7.3 | -30.0° | 3.0 | 38.0 | -16.2 |
| Model 3 | TSSVAAFVVGAVVSGFSVGWFVGLRER | 6.6 | -55.0° | 1.0 | 49.6 | -12.1 |
| Model 4 | TSSVAAFVVGAVVSGFSVGWFVGLRER | 7.3 | -47.2° | 3.3 | 53.8 | -5.3 |
| Model 5 | TSSVAAFVVGAVVSGFSVGWFVGLRER | 7.1 | -45.3° | 0.9 | 60.9 | -0.4 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 612, VAL, HA | A, 611, ALA, O | 3.18Å |
| B, 615, GLY, HA1 | A, 612, VAL, O | 2.78Å |
| B, 616, PHE, HA | A, 615, GLY, O | 2.27Å |
| B, 619, GLY, HA1 | A, 616, PHE, O | 2.92Å |
| A, 612, VAL, HA | B, 611, ALA, O | 3.18Å |
| A, 615, GLY, HA1 | B, 612, VAL, O | 2.78Å |
| A, 616, PHE, HA | B, 615, GLY, O | 2.27Å |
| A, 619, GLY, HA1 | B, 616, PHE, O | 2.92Å |
