UniProt data
UniProt name: TMPS5_HUMAN (Q9H3S3)
Gene name: TMPRSS5
Organism: Homo sapiens (Human).
Function: May play a role in hearing. {ECO:0000269|PubMed:17918732}.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Transmembrane domains:
- 50-70, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.
Sequence: 457 AA
10 20 30 40 50 60
MSLMLDDQPP MEAQYAEEGP GPGIFRAEPG DQQHPISQAV CWRSMRRGCA VLGALGLLAG
70 80 90 100 110 120
AGVGSWLLVL YLCPAASQPI SGTLQDEEIT LSCSEASAEE ALLPALPKTV SFRINSEDFL
130 140 150 160 170 180
LEAQVRDQPR WLLVCHEGWS PALGLQICWS LGHLRLTHHK GVNLTDIKLN SSQEFAQLSP
190 200 210 220 230 240
RLGGFLEEAW QPRNNCTSGQ VVSLRCSECG ARPLASRIVG GQSVAPGRWP WQASVALGFR
250 260 270 280 290 300
HTCGGSVLAP RWVVTAAHCM HSFRLARLSS WRVHAGLVSH SAVRPHQGAL VERIIPHPLY
310 320 330 340 350 360
SAQNHDYDVA LLRLQTALNF SDTVGAVCLP AKEQHFPKGS RCWVSGWGHT HPSHTYSSDM
370 380 390 400 410 420
LQDTVVPLFS TQLCNSSCVY SGALTPRMLC AGYLDGRADA CQGDSGGPLV CPDGDTWRLV
430 440 450
GVVSWGRGCA EPNHPGVYAK VAEFLDWIHD TAQDSLL
CATM prediction
The sequence of TMPS5_HUMAN returned 7 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 50 60 70 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | RGCAVLGALGLLAGAGVGSWLLVLYLC | 6.5 | -33.1° | 4.6 | 49.0 | -32.2 |
| Model 2 | RGCAVLGALGLLAGAGVGSWLLVLYLC | 6.3 | -54.0° | 4.8 | 40.9 | -20.1 |
| Model 3 | RGCAVLGALGLLAGAGVGSWLLVLYLC | 7.2 | -37.0° | -0.0 | 37.3 | -14.1 |
| Model 4 | RGCAVLGALGLLAGAGVGSWLLVLYLC | 6.6 | -51.9° | 1.3 | 57.1 | -13.5 |
| Model 5 | RGCAVLGALGLLAGAGVGSWLLVLYLC | 6.7 | -51.0° | 1.2 | 45.0 | -12.5 |
| Model 6 | RGCAVLGALGLLAGAGVGSWLLVLYLC | 6.5 | -52.8° | 3.1 | 34.2 | -5.8 |
| Model 7 | RGCAVLGALGLLAGAGVGSWLLVLYLC | 7.1 | +52.0° | 1.8 | 1.0 | -4.6 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 53, GLY, HA2 | A, 52, LEU, O | 3.47Å |
| B, 56, GLY, HA1 | A, 53, GLY, O | 3.03Å |
| B, 57, LEU, HA | A, 56, GLY, O | 2.39Å |
| B, 60, GLY, HA1 | A, 57, LEU, O | 2.95Å |
| B, 61, ALA, HA | A, 60, GLY, O | 3.42Å |
| A, 53, GLY, HA2 | B, 52, LEU, O | 3.47Å |
| A, 56, GLY, HA1 | B, 53, GLY, O | 3.03Å |
| A, 57, LEU, HA | B, 56, GLY, O | 2.39Å |
| A, 60, GLY, HA1 | B, 57, LEU, O | 2.95Å |
| A, 61, ALA, HA | B, 60, GLY, O | 3.42Å |
