Mucin-13

UniProt data

UniProt name: MUC13_HUMAN (Q9H3R2)

Gene name: MUC13; Synonyms=DRCC1, RECC; ORFNames=UNQ6194/PRO20221

Organism: Homo sapiens (Human).

Function: Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.

Subcellular location: Cell membrane {ECO:0000269|PubMed:11278439}; Single-pass type I membrane protein {ECO:0000269|PubMed:11278439}. Apical cell membrane {ECO:0000269|PubMed:11278439}. Secreted {ECO:0000269|PubMed:11278439}. Note=Also exists as a soluble form.

Transmembrane domains:

  1. 422-442, 21 AA, Helical. {ECO:0000255}.

Sequence: 512 AA

10 20 30 40 50 60 MKAIIHLTLL ALLSVNTATN QGNSADAVTT TETATSGPTV AAADTTETNF PETASTTANT 70 80 90 100 110 120 PSFPTATSPA PPIISTHSSS TIPTPAPPII STHSSSTIPI PTAADSESTT NVNSLATSDI 130 140 150 160 170 180 ITASSPNDGL ITMVPSETQS NNEMSPTTED NQSSGPPTGT ALLETSTLNS TGPSNPCQDD 190 200 210 220 230 240 PCADNSLCVK LHNTSFCLCL EGYYYNSSTC KKGKVFPGKI SVTVSETFDP EEKHSMAYQD 250 260 270 280 290 300 LHSEITSLFK DVFGTSVYGQ TVILTVSTSL SPRSEMRADD KFVNVTIVTI LAETTSDNEK 310 320 330 340 350 360 TVTEKINKAI RSSSSNFLNY DLTLRCDYYG CNQTADDCLN GLACDCKSDL QRPNPQSPFC 370 380 390 400 410 420 VASSLKCPDA CNAQHKQCLI KKSGGAPECA CVPGYQEDAN GNCQKCAFGY SGLDCKDKFQ 430 440 450 460 470 480 LILTIVGTIA GIVILSMIIA LIVTARSNNK TKHIEEENLI DEDFQNLKLR STGFTNLGAE 490 500 510 GSVFPKVRIT ASRDSQMQNP YSRHSSMPRP DY

CATM prediction

The sequence of MUC13_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   420       430       440   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 FQLILTIVGTIAGIVILSMIIALIVTA 6.5 -55.0° 4.9 52.8 -14.6
Model 2 FQLILTIVGTIAGIVILSMIIALIVTA 7.3 -55.1° 4.3 36.9 -12.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 427, GLY, HA1 A, 424, THR, O 3.14Å
B, 428, THR, HA A, 427, GLY, O 2.44Å
B, 431, GLY, HA1 A, 428, THR, O 3.09Å
A, 427, GLY, HA1 B, 424, THR, O 3.14Å
A, 428, THR, HA B, 427, GLY, O 2.44Å
A, 431, GLY, HA1 B, 428, THR, O 3.09Å