Thioredoxin-related transmembrane protein 1

UniProt data

UniProt name: TMX1_HUMAN (Q9H3N1)

Gene name: TMX1; Synonyms=TMX, TXNDC, TXNDC1

Organism: Homo sapiens (Human).

Function: May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly found in the endoplasmic reticulum. {ECO:0000269|PubMed:11152479}.

Transmembrane domains:

  1. 181-203, 23 AA, Helical. {ECO:0000255}.

Sequence: 280 AA

10 20 30 40 50 60 MAPSGSLAVP LAVLVLLLWG APWTHGRRSN VRVITDENWR ELLEGDWMIE FYAPWCPACQ 70 80 90 100 110 120 NLQPEWESFA EWGEDLEVNI AKVDVTEQPG LSGRFIITAL PTIYHCKDGE FRRYQGPRTK 130 140 150 160 170 180 KDFINFISDK EWKSIEPVSS WFGPGSVLMS SMSALFQLSM WIRTCHNYFI EDLGLPVWGS 190 200 210 220 230 240 YTVFALATLF SGLLLGLCMI FVADCLCPSK RRRPQPYPYP SKKLLSESAQ PLKKVEEEQE 250 260 270 ADEEDVSEEE AESKEGTNKD FPQNAIRQRS LGPSLATDKS

CATM prediction

The sequence of TMX1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    180       190       200    
  |    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 WGSYTVFALATLFSGLLLGLCMIFVADCL 6.9 -47.1° 1.4 44.9 -42.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 189, LEU, HA A, 188, THR, O 3.26Å
B, 192, GLY, HA1 A, 189, LEU, O 2.88Å
B, 193, LEU, HA A, 192, GLY, O 3.12Å
A, 181, TYR, HH B, 181, TYR, OH 2.15Å
A, 189, LEU, HA B, 188, THR, O 3.26Å
A, 192, GLY, HA1 B, 189, LEU, O 2.88Å
A, 193, LEU, HA B, 192, GLY, O 3.12Å