C-type lectin domain family 4 member M

UniProt data

UniProt name: CLC4M_HUMAN (Q9H2X3)

Gene name: CLEC4M; Synonyms=CD209L, CD209L1, CD299

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as an attachment receptor for ebola virus (PubMed:12050398, PubMed:12502850). Acts as an attachment receptor for hepatitis C virus (PubMed:15371595, PubMed:16816373). Acts as an attachment receptor for HIV-1 (PubMed:21277928, PubMed:12502850). Acts as an attachment receptor for human coronavirus 229E (PubMed:17037540). Acts as an attachment receptor for human cytomegalovirus/HHV-5 (PubMed:12433371). Acts as an attachment receptor for influenzavirus (PubMed:21191006). Acts as an attachment receptor for SARS coronavirus (PubMed:15479853). Acts as an attachment receptor for west-nile virus (PubMed:16415006). Acts as an attachment receptor for Japanese encephalitis virus (PubMed:24623090). Acts as an attachment receptor for Marburg virus glycoprotein (PubMed:15479853). Recognition of M.bovis by dendritic cells may occur partially via this molecule (PubMed:21203928). {ECO:0000269|PubMed:12050398, ECO:0000269|PubMed:12433371, ECO:0000269|PubMed:12502850, ECO:0000269|PubMed:15371595, ECO:0000269|PubMed:15479853, ECO:0000269|PubMed:16415006, ECO:0000269|PubMed:16816373, ECO:0000269|PubMed:17037540, ECO:0000269|PubMed:21191006, ECO:0000269|PubMed:21203928, ECO:0000269|PubMed:21277928, ECO:0000269|PubMed:24623090}.

Subcellular location: Isoform 10: Secreted {ECO:0000305}.

Transmembrane domains:

  1. 50-70, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000305}.

Sequence: 399 AA

10 20 30 40 50 60 MSDSKEPRVQ QLGLLEEDPT TSGIRLFPRD FQFQQIHGHK SSTGCLGHGA LVLQLLSFML 70 80 90 100 110 120 LAGVLVAILV QVSKVPSSLS QEQSEQDAIY QNLTQLKAAV GELSEKSKLQ EIYQELTQLK 130 140 150 160 170 180 AAVGELPEKS KLQEIYQELT RLKAAVGELP EKSKLQEIYQ ELTRLKAAVG ELPEKSKLQE 190 200 210 220 230 240 IYQELTRLKA AVGELPEKSK LQEIYQELTE LKAAVGELPE KSKLQEIYQE LTQLKAAVGE 250 260 270 280 290 300 LPDQSKQQQI YQELTDLKTA FERLCRHCPK DWTFFQGNCY FMSNSQRNWH DSVTACQEVR 310 320 330 340 350 360 AQLVVIKTAE EQNFLQLQTS RSNRFSWMGL SDLNQEGTWQ WVDGSPLSPS FQRYWNSGEP 370 380 390 NNSGNEDCAE FSGSGWNDNR CDVDNYWICK KPAACFRDE

CATM prediction

The sequence of CLC4M_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     50        60        70  
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 GHGALVLQLLSFMLLAGVLVAILVQVS 7.1 -44.0° 1.8 45.2 -22.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 60, LEU, HA A, 59, MET, O 3.18Å
B, 63, GLY, HA1 A, 60, LEU, O 3.00Å
B, 64, VAL, HA A, 63, GLY, O 3.36Å
A, 60, LEU, HA B, 59, MET, O 3.18Å
A, 63, GLY, HA1 B, 60, LEU, O 3.00Å
A, 64, VAL, HA B, 63, GLY, O 3.36Å