Synaptotagmin-4

UniProt data

UniProt name: SYT4_HUMAN (Q9H2B2)

Gene name: SYT4; Synonyms=KIAA1342

Organism: Homo sapiens (Human).

Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:P50232, ECO:0000269|PubMed:23999003}.

Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.

Transmembrane domains:

  1. 17-37, 21 AA, Helical. {ECO:0000255}.

Sequence: 425 AA

10 20 30 40 50 60 MAPITTSREE FDEIPTVVGI FSAFGLVFTV SLFAWICCQR KSSKSNKTPP YKFVHVLKGV 70 80 90 100 110 120 DIYPENLNSK KKFGADDKNE VKNKPAVPKN SLHLDLEKRD LNGNFPKTNL KPGSPSDLEN 130 140 150 160 170 180 ATPKLFLEGE KESVSPESLK SSTSLTSEEK QEKLGTLFFS LEYNFERKAF VVNIKEARGL 190 200 210 220 230 240 PAMDEQSMTS DPYIKMTILP EKKHKVKTRV LRKTLDPAFD ETFTFYGIPY TQIQELALHF 250 260 270 280 290 300 TILSFDRFSR DDIIGEVLIP LSGIELSEGK MLMNREIIKR NVRKSSGRGE LLISLCYQST 310 320 330 340 350 360 TNTLTVVVLK ARHLPKSDVS GLSDPYVKVN LYHAKKRISK KKTHVKKCTP NAVFNELFVF 370 380 390 400 410 420 DIPCEGLEDI SVEFLVLDSE RGSRNEVIGQ LVLGAAAEGT GGEHWKEICD YPRRQIAKWH VLCDG

CATM prediction

The sequence of SYT4_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        20        30        4
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 IATVVGIFSAFGLVFTVSLFAWICCQR 7.0 -43.0° 2.4 44.0 -15.3
Prolines* IPTVVGIFSAFGLVFTVSLFAWICCQR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 20, ILE, HA A, 19, GLY, O 3.39Å
A, 20, ILE, HA B, 19, GLY, O 3.39Å