Mucin-3B {ECO:0000305}

UniProt data

UniProt name: MUC3B_HUMAN (Q9H195)

Gene name: MUC3B {ECO:0000312|HGNC:HGNC:13384}

Organism: Homo sapiens (Human).

Function: Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 1141-1161, 21 AA, Helical. {ECO:0000255}.

Sequence: 1237 AA

10 20 30 40 50 60 MQLLGLLSIL WMLKSSPGAT GTLSTATSTS HVTFPRAEAT RTALSNSPHS RYLAEWPQGV 70 80 90 100 110 120 PQLASPAPGH RENAPMTLTT SPHDTLISET LLSSLVSSNT STTPTSKFAF KVETTPPTVL 130 140 150 160 170 180 VYSATTECVY PTSFIITISH STSICVTTTQ VTFTSSYTPT PVTQKPVTTV TRTYPMTTTE 190 200 210 220 230 240 KGTSAMISSP STTTARETPI VTVTPSSSVS ATDTTFHTTI SSTTRTTERT PLPTGSIHTT 250 260 270 280 290 300 MSPTPVFTTL KTAVTSTSPI TSTITSTNTV TSMTTTTSRP TATNTLSSLT SSILSSTPAP 310 320 330 340 350 360 NTEVITSHTT TTTPPSTLVT TLPTAIARST PTSETTPSFM SSIITTETTS HSTPSFSSST 370 380 390 400 410 420 IHSTVSSSTT AITSPFTTAE TGVTSTPSSP SSLSTDIPTT SLRTLTPLSL STSTSLTTTT 430 440 450 460 470 480 DLPSIPTDIS SLPTPIHIIS SSPSIQSTET SSLVGTTSPT MSTVRATLRS TENTPISSFS 490 500 510 520 530 540 TSIVVTPETP TTQAPPVLMS ATGTQTSPVP TTVTFGSMDS STSTLHTLTP STALSKIMST 550 560 570 580 590 600 SQFPIPSTHS STLQTTPSIP SLQTSLTSTS EFTTESFTRG STSTNAILTS FSTIIWSSTP 610 620 630 640 650 660 TIIMSSSPSS ASITPVFATT IHSVPSSPYI FSTENVGSAS ITAFPSLSSS STTSTSPTSS 670 680 690 700 710 720 SLTTALTEIT PFSYISLPST TPCPGTITIT IVPASPTDPC VEMDPSTEAT SPPTTPLTVF 730 740 750 760 770 780 PFTTEMVTCP SSISMQTTLA THMDTSSMTP ESESSIIPNA SSSTGTGTVP TNTVFTSTRL 790 800 810 820 830 840 PTSETWLSNN SVIPTPLPGV STIPLTMKPS SSLPTILRTS SKSTHPSPPT ARTSQTSVAT 850 860 870 880 890 900 TQTPTTLTTC RTTPITSWMT TQSTLTTTAG TCDNGGTWEQ GQCACLPGFS GDRCQLQTRC 910 920 930 940 950 960 QNGGQWDGLK CQCPSTFYGS SCEFAVEQVD LDVVETEVGM EVSVDQQFSP DLNDNTSQAY 970 980 990 1000 1010 1020 RDFNKTFWNQ MQKIFADMQG FTFKGVEILS LRNGSIVVDY LVLLEMPFSP QLESEYEQVK 1030 1040 1050 1060 1070 1080 TTLKEGLQNA SQDANSCQDS QALCFKPDSI KVNNNSKTEL TPEAICRRAA PTGYEEFYFP 1090 1100 1110 1120 1130 1140 LVEATRLRCV TKCTSGLDNA IDCHQGQCVL ETSGPACRCY STDTHWFSGP RCEVTVHWRA 1150 1160 1170 1180 1190 1200 LVGGLTAGAA LLVLLLLALG VRAVRSEWWG RQRRGRSWDQ DRKWFETWDE EVVGTFSNWG 1210 1220 1230 FEDDGTDKDT NFHVALENVD TTMKVHIKRP EMTSSSV

CATM prediction

The sequence of MUC3B_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          810       820      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 WRALVGGLTAGAALLVLLLLALGVRAV 7.1 -30.0° 5.7 37.0 -31.2
Model 2 WRALVGGLTAGAALLVLLLLALGVRAV 6.9 -48.0° 0.0 38.0 -23.2
Model 3 WRALVGGLTAGAALLVLLLLALGVRAV 6.7 -53.0° 3.1 34.0 -17.7
Model 4 WRALVGGLTAGAALLVLLLLALGVRAV 7.2 -44.0° 5.0 44.0 -17.6
Model 5 WRALVGGLTAGAALLVLLLLALGVRAV 7.2 -47.6° 0.0 37.8 -4.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 808, GLY, HA1 A, 805, LEU, O 3.40Å
A, 808, GLY, HA1 B, 805, LEU, O 3.40Å