Cadherin-19

UniProt data

UniProt name: CAD19_HUMAN (Q9H159)

Gene name: CDH19; Synonyms=CDH7L2; ORFNames=UNQ478/PRO941

Organism: Homo sapiens (Human).

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 597-617, 21 AA, Helical. {ECO:0000255}.

Sequence: 772 AA

10 20 30 40 50 60 MNCYLLLRFM LGIPLLWPCL GATENSQTKK VKQPVRSHLR VKRGWVWNQF FVPEEMNTTS 70 80 90 100 110 120 HHIGQLRSDL DNGNNSFQYK LLGAGAGSTF IIDERTGDIY AIQKLDREER SLYILRAQVI 130 140 150 160 170 180 DIATGRAVEP ESEFVIKVSD INDNEPKFLD EPYEAIVPEM SPEGTLVIQV TASDADDPSS 190 200 210 220 230 240 GNNARLLYSL LQGQPYFSVE PTTGVIRISS KMDRELQDEY WVIIQAKDMI GQPGALSGTT 250 260 270 280 290 300 SVLIKLSDVN DNKPIFKESL YRLTVSESAP TGTSIGTIMA YDNDIGENAE MDYSIEEDDS 310 320 330 340 350 360 QTFDIITNHE TQEGIVILKK KVDFEHQNHY GIRAKVKNHH VPEQLMKYHT EASTTFIKIQ 370 380 390 400 410 420 VEDVDEPPLF LLPYYVFEVF EETPQGSFVG VVSATDPDNR KSPIRYSITR SKVFNINDNG 430 440 450 460 470 480 TITTSNSLDR EISAWYNLSI TATEKYNIEQ ISSIPLYVQV LNINDHAPEF SQYYETYVCE 490 500 510 520 530 540 NAGSGQVIQT ISAVDRDESI EEHHFYFNLS VEDTNNSSFT IIDNQDNTAV ILTNRTGFNL 550 560 570 580 590 600 QEEPVFYISI LIADNGIPSL TSTNTLTIHV CDCGDSGSTQ TCQYQELVLS MGFKTEVIIA 610 620 630 640 650 660 ILICIMIIFG FIFLTLGLKQ RRKQILFPEK SEDFRENIFQ YDDEGGGEED TEAFDIAELR 670 680 690 700 710 720 SSTIMRERKT RKTTSAEIRS LYRQSLQVGP DSAIFRKFIL EKLEEANTDP CAPPFDSLQT 730 740 750 760 770 YAFEGTGSLA GSLSSLESAV SDQDESYDYL NELGPRFKRL ACMFGSAVQS NN

CATM prediction

The sequence of CAD19_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        600       610       6
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 KTEVIIAILICIMIIFGFIFLTLGLKQ 7.0 -37.1° -0.0 37.1 -21.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 614, LEU, HA A, 613, PHE, O 2.96Å
B, 617, GLY, HA1 A, 614, LEU, O 3.43Å
A, 614, LEU, HA B, 613, PHE, O 2.96Å
A, 617, GLY, HA1 B, 614, LEU, O 3.43Å