Protocadherin alpha-C1

UniProt data

UniProt name: PCDC1_HUMAN (Q9H158)

Gene name: PCDHAC1

Organism: Homo sapiens (Human).

Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 684-704, 21 AA, Helical. {ECO:0000255}.

Sequence: 963 AA

10 20 30 40 50 60 MVGCGVAVLC LWVSCGAAAG QLEYSVPEET ERGVAVGNLS ADLRLPAAAM SSRNFRFLSS 70 80 90 100 110 120 HRELYFGVDL PSGNLVVREP ADREQLCRAK AACVLTYDLV LEDPLELHKI RIHVLDTNDN 130 140 150 160 170 180 SPLFPAGDVQ LHIPEFLTPG ARFTLPNAQD DDEGSNGILS YSLSPSQHFR LDMGSRVDGS 190 200 210 220 230 240 EYPELVLEKA LDREQRATHL LVLTARDGGL PARSGDAQVT IIVVDTNDNA PVFERSVYRT 250 260 270 280 290 300 KVPETAPNGT VLFRVQALDP DEGSNGEVQY SLSNSTQAEL RHRFHVHPKS GEVQVAASLG 310 320 330 340 350 360 PPETLLEAYI EARDEGVFGL ASTAKLLVEV TDVNDHAPEL DFLTLSNPVP EDAAPGTVIA 370 380 390 400 410 420 LFSVKDEDLD SNGRVICGMS SAGPFQLTAS FDNYYSLLID GPLDREQISE YQVLITASDS 430 440 450 460 470 480 GSPPLSTRRT ITVSVADVND NTPNFPQPQQ ELFVAENNGP GASLGRVFAQ DPDLGKNGLV 490 500 510 520 530 540 SYELLDVISE GPSASSLLAV ESSSGAITAK TSFDFEQLRG FHFQVEGRDG GIPPRSATVT 550 560 570 580 590 600 INLFVVDRND NYPVILFPLP RNGSVPVEIV PRSARTGHLV TKVVAEDADS GSNAWLSYHI 610 620 630 640 650 660 SRASDSSLFR ISANIGELRT ARLVLPTDAV KQRVVVVVRD HGDPPLSSSV TLGVLLSNSV 670 680 690 700 710 720 PQLLPDFEDV WEPGGQLSAQ NLYLVIALAC ISFLFLGCLL FFVCTKLHQS PGCCAQSCCR 730 740 750 760 770 780 STEDLRYGSK MVSNPCMTSA TIDVTTVERL SQTYLYRASL GLGSDNNSLL LRGEYNAADL 790 800 810 820 830 840 RNLATGVGLN LPISCIQIRN RKGDHANVNA MPRQPNPDWR YSASLRAGMH SSVHLEEAGI 850 860 870 880 890 900 LRAGPGGPDQ QWPTVSSATP EPEAGEVSPP VGAGVNSNSW TFKYGPGNPK QSGPGELPDK 910 920 930 940 950 960 FIIPGSPAII SIRQEPTNSQ IDKSDFITFG KKEETKKKKK KKKGNKTQEK KEKGNSTTDN SDQ

CATM prediction

The sequence of PCDC1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           690       700     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 NLYLVIALACISFLFLGCLLFFVCTKL 7.2 -55.1° 2.4 48.0 -16.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 694, LEU, HA A, 693, PHE, O 3.44Å
B, 697, GLY, HA1 A, 694, LEU, O 3.19Å
A, 694, LEU, HA B, 693, PHE, O 3.44Å
A, 697, GLY, HA1 B, 694, LEU, O 3.19Å