VIP36-like protein

UniProt data

UniProt name: LMA2L_HUMAN (Q9H0V9)

Gene name: LMAN2L; Synonyms=VIPL; ORFNames=PSEC0028, UNQ368/PRO704

Organism: Homo sapiens (Human).

Function: May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53. {ECO:0000269|PubMed:12878160}.

Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Predominantly found in the endoplasmic reticulum. Partly found in the Golgi.

Transmembrane domains:

  1. 314-336, 23 AA, Helical. {ECO:0000255}.

Sequence: 348 AA

10 20 30 40 50 60 MAATLGPLGS WQQWRRCLSA RDGSRMLLLL LLLGSGQGPQ QVGAGQTFEY LKREHSLSKP 70 80 90 100 110 120 YQGVGTGSSS LWNLMGNAMV MTQYIRLTPD MQSKQGALWN RVPCFLRDWE LQVHFKIHGQ 130 140 150 160 170 180 GKKNLHGDGL AIWYTKDRMQ PGPVFGNMDK FVGLGVFVDT YPNEEKQQER VFPYISAMVN 190 200 210 220 230 240 NGSLSYDHER DGRPTELGGC TAIVRNLHYD TFLVIRYVKR HLTIMMDIDG KHEWRDCIEV 250 260 270 280 290 300 PGVRLPRGYY FGTSSITGDL SDNHDVISLK LFELTVERTP EEEKLHRDVF LPSVDNMKLP 310 320 330 340 EMTAPLPPLS GLALFLIVFF SLVFSVFAIV IGIILYNKWQ EQSRKRFY

CATM prediction

The sequence of LMA2L_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           320       330       
    +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 GLALFLIVFFSLVFSVFAIVIGIILYNKW 7.3 -54.0° 3.6 48.6 -27.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 329, ILE, HA A, 328, ALA, O 3.26Å
B, 332, GLY, HA1 A, 329, ILE, O 3.44Å
A, 329, ILE, HA B, 328, ALA, O 3.26Å
A, 332, GLY, HA1 B, 329, ILE, O 3.44Å