Disintegrin and metalloproteinase domain-containing protein 19

UniProt data

UniProt name: ADA19_HUMAN (Q9H013)

Gene name: ADAM19; Synonyms=MLTNB; ORFNames=FKSG34

Organism: Homo sapiens (Human).

Function: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). {ECO:0000250}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 700-720, 21 AA, Helical. {ECO:0000255}.

Sequence: 955 AA

10 20 30 40 50 60 MPGGAGAARL CLLAFALQPL RPRAAREPGW TRGSEEGSPK LQHELIIPQW KTSESPVREK 70 80 90 100 110 120 HPLKAELRVM AEGRELILDL EKNEQLFAPS YTETHYTSSG NPQTTTRKLE DHCFYHGTVR 130 140 150 160 170 180 ETELSSVTLS TCRGIRGLIT VSSNLSYVIE PLPDSKGQHL IYRSEHLKPP PGNCGFEHSK 190 200 210 220 230 240 PTTRDWALQF TQQTKKRPRR MKREDLNSMK YVELYLVADY LEFQKNRRDQ DATKHKLIEI 250 260 270 280 290 300 ANYVDKFYRS LNIRIALVGL EVWTHGNMCE VSENPYSTLW SFLSWRRKLL AQKYHDNAQL 310 320 330 340 350 360 ITGMSFHGTT IGLAPLMAMC SVYQSGGVNM DHSENAIGVA ATMAHEMGHN FGMTHDSADC 370 380 390 400 410 420 CSASAADGGC IMAAATGHPF PKVFNGCNRR ELDRYLQSGG GMCLSNMPDT RMLYGGRRCG 430 440 450 460 470 480 NGYLEDGEEC DCGEEEECNN PCCNASNCTL RPGAECAHGS CCHQCKLLAP GTLCREQARQ 490 500 510 520 530 540 CDLPEFCTGK SPHCPTNFYQ MDGTPCEGGQ AYCYNGMCLT YQEQCQQLWG PGARPAPDLC 550 560 570 580 590 600 FEKVNVAGDT FGNCGKDMNG EHRKCNMRDA KCGKIQCQSS EARPLESNAV PIDTTIIMNG 610 620 630 640 650 660 RQIQCRGTHV YRGPEEEGDM LDPGLVMTGT KCGYNHICFE GQCRNTSFFE TEGCGKKCNG 670 680 690 700 710 720 HGVCNNNQNC HCLPGWAPPF CNTPGHGGSI DSGPMPPESV GPVVAGVLVA ILVLAVLMLM 730 740 750 760 770 780 YYCCRQNNKL GQLKPSALPS KLRQQFSCPF RVSQNSGTGH ANPTFKLQTP QGKRKVINTP 790 800 810 820 830 840 EILRKPSQPP PRPPPDYLRG GSPPAPLPAH LSRAARNSPG PGSQIERTES SRRPPPSRPI 850 860 870 880 890 900 PPAPNCIVSQ DFSRPRPPQK ALPANPVPGR RSLPRPGGAS PLRPPGAGPQ QSRPLAALAP 910 920 930 940 950 KVSPREALKV KAGTRGLQGG RCRVEKTKQF MLLVVWTELP EQKPRAKHSC FLVPA

CATM prediction

The sequence of ADA19_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     700       710       720 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 AESVGAVVAGVLVAILVLAVLMLMYYC 7.0 -49.7° 2.9 47.1 -22.2
Model 2 AESVGAVVAGVLVAILVLAVLMLMYYC 6.6 -49.0° 1.8 45.0 -4.8
Prolines* PESVGPVVAGVLVAILVLAVLMLMYYC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 703, VAL, HA A, 702, ALA, O 3.14Å
B, 706, GLY, HA1 A, 703, VAL, O 3.04Å
A, 703, VAL, HA B, 702, ALA, O 3.14Å
A, 706, GLY, HA1 B, 703, VAL, O 3.04Å