Linker for activation of T-cells family member 2

UniProt data

UniProt name: NTAL_HUMAN (Q9GZY6)

Gene name: LAT2; Synonyms=LAB, NTAL, WBS15, WBSCR15, WBSCR5

Organism: Homo sapiens (Human).

Function: Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734}; Single-pass type III membrane protein {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734}. Note=Present in lipid rafts.

Transmembrane domains:

  1. 6-26, 21 AA, Helical; Signal-anchor for type III membrane protein. {ECO:0000255}.

Sequence: 243 AA

10 20 30 40 50 60 MSSGTELLWP GAALLVLLGV AASLCVRCSR PGAKRSEKIY QQRSLREDQQ SFTGSRTYSL 70 80 90 100 110 120 VGQAWPGPLA DMAPTRKDKL LQFYPSLEDP ASSRYQNFSK GSRHGSEEAY IDPIAMEYYN 130 140 150 160 170 180 WGRFSKPPED DDANSYENVL ICKQKTTETG AQQEGIGGLC RGDLSLSLAL KTGPTSGLCP 190 200 210 220 230 240 SASPEEDEES EDYQNSASIH QWRESRKVMG QLQREASPGP VGSPDEEDGE PDYVNGEVAA TEA

CATM prediction

The sequence of NTAL_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         10        20        
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 SGTELLWAGAALLVLLGVAASLCVRCS 7.3 -47.0° 1.4 44.6 -1.1
Prolines* SGTELLWPGAALLVLLGVAASLCVRCS          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 19, GLY, HA1 A, 16, VAL, O 3.28Å
B, 20, VAL, HA A, 19, GLY, O 3.46Å
B, 23, SER, HG1 A, 20, VAL, O 2.57Å
A, 19, GLY, HA1 B, 16, VAL, O 3.28Å
A, 20, VAL, HA B, 19, GLY, O 3.46Å
A, 23, SER, HG1 B, 20, VAL, O 2.57Å