UniProt data
UniProt name: COA1_HUMAN (Q9GZY4)
Gene name: COA1; Synonyms=C7orf44, MITRAC15
Organism: Homo sapiens (Human).
Function: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV. {ECO:0000269|PubMed:23260140}.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:22356826, ECO:0000269|PubMed:23260140}; Single-pass membrane protein {ECO:0000269|PubMed:22356826, ECO:0000269|PubMed:23260140}.
Transmembrane domains:
- 15-37, 23 AA, Helical. {ECO:0000255}.
Sequence: 146 AA
CATM prediction
The sequence of COA1_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 20 30 4 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | SMALGARILFHGVFYAGGFAIVYYLIQKF | 7.4 | -47.0° | 2.3 | 45.1 | -27.0 |
| Prolines* | SMPLGARILFHGVFYAGGFAIVYYLIQKF |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 20, LEU, HA | A, 19, ILE, O | 3.49Å |
| B, 23, GLY, HA1 | A, 20, LEU, O | 3.33Å |
| A, 20, LEU, HA | B, 19, ILE, O | 3.49Å |
| A, 23, GLY, HA1 | B, 20, LEU, O | 3.33Å |
| A, 35, TYR, HH | B, 35, TYR, OH | 2.07Å |