N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4

UniProt data

UniProt name: B3GN4_HUMAN (Q9C0J1)

Gene name: B3GNT4; ORFNames=UNQ1898/PRO4344

Organism: Homo sapiens (Human).

Function: Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides. {ECO:0000269|PubMed:11042166}.

Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 29-49, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 378 AA

10 20 30 40 50 60 MLPPQPSAAH QGRGGRSGLL PKGPAMLCRL CWLVSYSLAV LLLGCLLFLR KAAKPAGDPT 70 80 90 100 110 120 AHQPFWAPPT PRHSRCPPNH TVSSASLSLP SRHRLFLTYR HCRNFSILLE PSGCSKDTFL 130 140 150 160 170 180 LLAIKSQPGH VERRAAIRST WGRVGGWARG RQLKLVFLLG VAGSAPPAQL LAYESREFDD 190 200 210 220 230 240 ILQWDFTEDF FNLTLKELHL QRWVVAACPQ AHFMLKGDDD VFVHVPNVLE FLDGWDPAQD 250 260 270 280 290 300 LLVGDVIRQA LPNRNTKVKY FIPPSMYRAT HYPPYAGGGG YVMSRATVRR LQAIMEDAEL 310 320 330 340 350 360 FPIDDVFVGM CLRRLGLSPM HHAGFKTFGI RRPLDPLDPC LYRGLLLVHR LSPLEMWTMW 370 ALVTDEGLKC AAGPIPQR

CATM prediction

The sequence of B3GN4_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      30        40        50 
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 MLCRLCWLVSYSLAVLLLGCLLFLRKA 7.3 -51.2° 2.4 45.0 -16.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 36, TYR, HH A, 37, SER, OG 2.12Å
B, 41, LEU, HA A, 40, VAL, O 3.45Å
B, 44, GLY, HA1 A, 41, LEU, O 3.24Å
A, 36, TYR, HH B, 37, SER, OG 2.12Å
A, 41, LEU, HA B, 40, VAL, O 3.45Å
A, 44, GLY, HA1 B, 41, LEU, O 3.24Å