UniProt data
UniProt name: THS7B_HUMAN (Q9C0I4)
Gene name: THSD7B; Synonyms=KIAA1679
Organism: Homo sapiens (Human).
Function:
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Transmembrane domains:
- 1558-1578, 21 AA, Helical. {ECO:0000255}.
Sequence: 1608 AA
10 20 30 40 50 60
MFPKSNLTVT CWVWRSMRKL FLLLSLLLSH AAHLEGKKDN QFIWKTGPWG RCTGDCGPGG
70 80 90 100 110 120
VQSRAVWCFH VDGWTSHLSN CGESNRPPKE RSCFRVCDWH SDLFQWEVSD WHHCVLVPYA
130 140 150 160 170 180
RGEVKPRTAE CVTAQHGLQH RMVRCIQKLN RTVVANEICE HFALQPPTEQ ACLIPCPRDC
190 200 210 220 230 240
VVSEFLPWSN CSKGCGKKLQ HRTRAVIAPP LFGGLQCPNL TESRACDAPI SCPLGEEEYT
250 260 270 280 290 300
FSLKVGPWSK CRLPHLKEIN PSGRTVLDFN SDSNERVTFK HQSYKAHHHS KSWAIEIGYQ
310 320 330 340 350 360
TRQVSCTRSD GQNAMLSLCL QDSFPLTVQS CIMPKDCETS QWSSWSPCSK TCRSGSLLPG
370 380 390 400 410 420
FRSRSRNVKH MAIGGGKECP ELLEKEACIV EGELLQQCPR YSWRTSEWKE CQVSLLLEQQ
430 440 450 460 470 480
DPHWHVTGPV CGGGIQTREV YCAQSVPAAA ALRAKEVSRP VEKALCVGPA PLPSQLCNIP
490 500 510 520 530 540
CSTDCIVSSW SAWGLCIHEN CHDPQGKKGF RTRQRHVLME STGPAGHCPH LVESVPCEDP
550 560 570 580 590 600
MCYRWLASEG ICFPDHGKCG LGHRILKAVC QNDRGEDVSG SLCPVPPPPE RKSCEIPCRM
610 620 630 640 650 660
DCVLSEWTEW SSCSQSCSNK NSDGKQTRSR TILALAGEGG KPCPPSQALQ EHRLCNDHSC
670 680 690 700 710 720
MQLHWETSPW GPCSEDTLVT ALNATIGWNG EATCGVGIQT RRVFCVKSHV GQVMTKRCPD
730 740 750 760 770 780
STRPETVRPC FLPCKKDCIV TAFSEWTPCP RMCQAGNATV KQSRYRIIIQ EAANGGQECP
790 800 810 820 830 840
DTLYEERECE DVSLCPVYRW KPQKWSPCIL VPESVWQGIT GSSEACGKGL QTRAVSCISD
850 860 870 880 890 900
DNRSAEMMEC LKQTNGMPLL VQECTVPCRE DCTFTAWSKF TPCSTNCEAT KSRRRQLTGK
910 920 930 940 950 960
SRKKEKCQDS DLYPLVETEL CPCDEFISQP YGNWSDCILP EGRREPHRGL RVQADSKECG
970 980 990 1000 1010 1020
EGLRFRAVAC SDKNGRPVDP SFCSSSGYIQ EKCVIPCPFD CKLSDWSSWG SCSSSCGIGV
1030 1040 1050 1060 1070 1080
RIRSKWLKEK PYNGGRPCPK LDLKNQAQVH EAVPCYSECN QYSWVVEHWS SCKINNELRS
1090 1100 1110 1120 1130 1140
LRCGGGTQSR KIRCVNTADG EGGAVDSNLC NQDEIPPETQ SCSLMCPNEC VMSEWGLWSK
1150 1160 1170 1180 1190 1200
CPQSCDPHTM QRRTRHLLRP SLNSRTCAED SQVQPCLLNE NCFQFQYNLT EWSTCQLSEN
1210 1220 1230 1240 1250 1260
APCGQGVRTR LLSCVCSDGK PVSMDQCEQH NLEKPQRMSI PCLVECVVNC QLSGWTAWTE
1270 1280 1290 1300 1310 1320
CSQTCGHGGR MSRTRFIIMP TQGEGRPCPT ELTQEKTCPV TPCYSWVLGN WSACKLEGGD
1330 1340 1350 1360 1370 1380
CGEGVQIRSL SCMVHSGSIS HAAGRVEDAL CGEMPFQDSI LKQLCSVPCP GDCHLTEWSE
1390 1400 1410 1420 1430 1440
WSTCELTCID GRSFETVGRQ SRSRTFIIQS FENQDSCPQQ VLETRPCTGG KCYHYTWKAS
1450 1460 1470 1480 1490 1500
LWNNNERTVW CQRSDGVNVT GGCSPQARPA AIRQCIPACR KPFSYCTQGG VCGCEKGYTE
1510 1520 1530 1540 1550 1560
IMKSNGFLDY CMKVPGSEDK KADVKNLSGK NRPVNSKIHD IFKGWSLQPL DPDGRVKIWV
1570 1580 1590 1600
YGVSGGAFLI MIFLIFTSYL VCKKPKPHQS TPPQQKPLTL AYDGDLDM
CATM prediction
The sequence of THS7B_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 1560 1570 15 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | RVKIWVYGVSGGAFLIMIFLIFTSYLV | 6.6 | -55.2° | 4.9 | 53.0 | -27.9 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 1562, GLY, HA1 | A, 1559, TRP, O | 3.38Å |
| B, 1563, VAL, HA | A, 1562, GLY, O | 2.55Å |
| B, 1566, GLY, HA1 | A, 1563, VAL, O | 3.11Å |
| A, 1562, GLY, HA1 | B, 1559, TRP, O | 3.38Å |
| A, 1563, VAL, HA | B, 1562, GLY, O | 2.55Å |
| A, 1566, GLY, HA1 | B, 1563, VAL, O | 3.11Å |