Contactin-associated protein-like 4

UniProt data

UniProt name: CNTP4_HUMAN (Q9C0A0)

Gene name: CNTNAP4; Synonyms=CASPR4, KIAA1763

Organism: Homo sapiens (Human).

Function: Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity). {ECO:0000250}.

Subcellular location: Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Specifically present within the presynaptic compartment of synapses. {ECO:0000250}.

Transmembrane domains:

  1. 1242-1262, 21 AA, Helical. {ECO:0000255}.

Sequence: 1308 AA

10 20 30 40 50 60 MGSVTGAVLK TLLLLSTQNW NRVEAGNSYD CDDPLVSALP QASFSSSSEL SSSHGPGFAR 70 80 90 100 110 120 LNRRDGAGGW SPLVSNKYQW LQIDLGERME VTAVATQGGY GSSNWVTSYL LMFSDSGWNW 130 140 150 160 170 180 KQYRQEDSIW GFSGNANADS VVYYRLQPSI KARFLRFIPL EWNPKGRIGM RIEVFGCAYR 190 200 210 220 230 240 SEVVDLDGKS SLLYRFDQKS LSPIKDIISL KFKTMQSDGI LLHREGPNGD HITLQLRRAR 250 260 270 280 290 300 LFLLINSGEA KLPSTSTLVN LTLGSLLDDQ HWHSVLIQRL GKQVNFTVDE HRHHFHARGE 310 320 330 340 350 360 FNLMNLDYEI SFGGIPAPGK SVSFPHRNFH GCLENLYYNG VDIIDLAKQQ KPQIIAMGNV 370 380 390 400 410 420 SFSCSQPQSM PVTFLSSRSY LALPDFSGEE EVSATFQFRT WNKAGLLLFS ELQLISGGIL 430 440 450 460 470 480 LFLSDGKLKS NLYQPGKLPS DITAGVELND GQWHSVSLSA KKNHLSVAVD GQMASAAPLL 490 500 510 520 530 540 GPEQIYSGGT YYFGGCPDKS FGSKCKSPLG GFQGCMRLIS ISGKVVDLIS VQQGSLGNFS 550 560 570 580 590 600 DLQIDSCGIS DRCLPNYCEH GGECSQSWST FHCNCTNTGY RGATCHNSIY EQSCEAYKHR 610 620 630 640 650 660 GNTSGFYYID SDGSGPLEPF LLYCNMTETA WTIIQHNGSD LTRVRNTNPE NPYAGFFEYV 670 680 690 700 710 720 ASMEQLQATI NRAEHCEQEF TYYCKKSRLV NKQDGTPLSW WVGRTNETQT YWGGSSPDLQ 730 740 750 760 770 780 KCTCGLEGNC IDSQYYCNCD ADRNEWTNDT GLLAYKEHLP VTKIVITDTG RLHSEAAYKL 790 800 810 820 830 840 GPLLCQGDRS FWNSASFDTE ASYLHFPTFH GELSADVSFF FKTTASSGVF LENLGIADFI 850 860 870 880 890 900 RIELRSPTVV TFSFDVGNGP FEISVQSPTH FNDNQWHHVR VERNMKEASL QVDQLTPKTQ 910 920 930 940 950 960 PAPADGHVLL QLNSQLFVGG TATRQRGFLG CIRSLQLNGM TLDLEERAQV TPEVQPGCRG 970 980 990 1000 1010 1020 HCSSYGKLCR NGGKCRERPI GFFCDCTFSA YTGPFCSNEI SAYFGSGSSV IYNFQENYLL 1030 1040 1050 1060 1070 1080 SKNSSSHAAS FHGDMKLSRE MIKFSFRTTR TPSLLLFVSS FYKEYLSVII AKNGSLQIRY 1090 1100 1110 1120 1130 1140 KLNKYQEPDV VNFDFKNMAD GQLHHIMINR EEGVVFIEID DNRRRQVHLS SGTEFSAVKS 1150 1160 1170 1180 1190 1200 LVLGRILEHS DVDQDTALAG AQGFTGCLSA VQLSHVAPLK AALHPSHPDP VTVTGHVTES 1210 1220 1230 1240 1250 1260 SCMAQPGTDA TSRERTHSFA DHSGTIDDRE PLANAIKSDS AVIGGLIAVV IFILLCITAI 1270 1280 1290 1300 AVRIYQQKRL YKRSEAKRSE NVDSAEAVLK SELNIQNAVN ENQKEYFF

CATM prediction

The sequence of CNTP4_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   1240      1250      1260  
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 DSAVIGGLIAVVIFILLCITAIAVRIY 6.6 -47.0° 2.2 45.0 -19.8
Model 2 DSAVIGGLIAVVIFILLCITAIAVRIY 7.0 -52.0° 5.2 40.0 -1.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1245, GLY, HA2 A, 1244, GLY, O 3.12Å
A, 1245, GLY, HA2 B, 1244, GLY, O 3.12Å