Sialoadhesin

UniProt data

UniProt name: SN_HUMAN (Q9BZZ2)

Gene name: SIGLEC1; Synonyms=SN

Organism: Homo sapiens (Human).

Function: Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. {ECO:0000250}.

Subcellular location: Isoform 2: Secreted.

Transmembrane domains:

  1. 1642-1662, 21 AA, Helical. {ECO:0000255}.

Sequence: 1709 AA

10 20 30 40 50 60 MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE VPDGITAIWY 70 80 90 100 110 120 YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL LLKDLQPEDS GSYNFRFEIS 130 140 150 160 170 180 EVNRWSDVKG TLVTVTEEPR VPTIASPVEL LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP 190 200 210 220 230 240 ARSVTFNSQK FEPTGVGHLE TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG 250 260 270 280 290 300 VKILLSPSGR NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA 310 320 330 340 350 360 GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN EAPSDLRYSW 370 380 390 400 410 420 YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER SGPVSVVVNH PPLTPVLTAF 430 440 450 460 470 480 LETQAGLVGI LHCSVVSEPL ATLVLSHGGH ILASTSGDSD HSPRFSGTSG PNSLRLEIRD 490 500 510 520 530 540 LEETDSGEYK CSATNSLGNA TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD 550 560 570 580 590 600 ARFSWYLNGA LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ 610 620 630 640 650 660 PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG GGCSTCGGCS 670 680 690 700 710 720 PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST SATFNGQATV LAIAPSHTLQ 730 740 750 760 770 780 EGTEANLTCN VSREAAGSPA NFSWFRNGVL WAQGPLETVT LLPVARTDAA LYACRILTEA 790 800 810 820 830 840 GAQLSTPVLL SVLYPPDRPK LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL 850 860 870 880 890 900 GPQVPSHGRF QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV 910 920 930 940 950 960 SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI TLTQAGAYHC 970 980 990 1000 1010 1020 QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL GLLLCRVDSD PPAQLRLLHG 1030 1040 1050 1060 1070 1080 DRLVASTLQG VGGPEGSSPR LHVAVAPNTL RLEIHGAMLE DEGVYICEAS NTLGQASASA 1090 1100 1110 1120 1130 1140 DFDAQAVNVQ VWPGATVREG QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT 1150 1160 1170 1180 1190 1200 VRDATSYRCG VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP 1210 1220 1230 1240 1250 1260 AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA NTSLELRLEG 1270 1280 1290 1300 1310 1320 VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW LQEGPAASLS FLVATRAHAG 1330 1340 1350 1360 1370 1380 AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV LSSFRDSRAR SMAVIQCTVD SEPPAELALS 1390 1400 1410 1420 1430 1440 HDGKVLATSS GVHSLASGTG HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL 1450 1460 1470 1480 1490 1500 QVEGARVVAE PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH 1510 1520 1530 1540 1550 1560 VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG ILDCRVDSEP 1570 1580 1590 1600 1610 1620 LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI EALRPSDQGE YICSASNVLG 1630 1640 1650 1660 1670 1680 SASTSTYFGV RALHRLHQFQ QLLWVLGLLV GLLLLLLGLG ACYTWRRRRV CKQSMGENSV 1690 1700 EMAFQKETTQ LIDPDAATCE TSTCAPPLG

CATM prediction

The sequence of SN_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   1640      1650      1660  
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 FQQLLWVLGLLVGLLLLLLGLGACYTW 6.8 -55.0° 1.5 45.2 -11.4
Model 2 FQQLLWVLGLLVGLLLLLLGLGACYTW 7.4 -41.0° 3.5 37.9 -1.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1644, TRP, HA A, 1643, LEU, O 3.29Å
B, 1647, GLY, HA1 A, 1644, TRP, O 2.67Å
B, 1648, LEU, HA A, 1647, GLY, O 3.14Å
A, 1644, TRP, HA B, 1643, LEU, O 3.29Å
A, 1647, GLY, HA1 B, 1644, TRP, O 2.67Å
A, 1648, LEU, HA B, 1647, GLY, O 3.14Å