Interphotoreceptor matrix proteoglycan 2

UniProt data

UniProt name: IMPG2_HUMAN (Q9BZV3)

Gene name: IMPG2; Synonyms=IPM200

Organism: Homo sapiens (Human).

Function: Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light- sensitive photoreceptor outer segment. Binds heparin. {ECO:0000269|PubMed:10702256}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 1100-1120, 21 AA, Helical. {ECO:0000255}.

Sequence: 1241 AA

10 20 30 40 50 60 MIMFPLFGKI SLGILIFVLI EGDFPSLTAQ TYLSIEEIQE PKSAVSFLLP EESTDLSLAT 70 80 90 100 110 120 KKKQPLDRRE TERQWLIRRR RSILFPNGVK ICPDESVAEA VANHVKYFKV RVCQEAVWEA 130 140 150 160 170 180 FRTFWDRLPG REEYHYWMNL CEDGVTSIFE MGTNFSESVE HRSLIMKKLT YAKETVSSSE 190 200 210 220 230 240 LSSPVPVGDT STLGDTTLSV PHPEVDAYEG ASESSLERPE ESISNEIENV IEEATKPAGE 250 260 270 280 290 300 QIAEFSIHLL GKQYREELQD SSSFHHQHLE EEFISEVENA FTGLPGYKEI RVLEFRSPKE 310 320 330 340 350 360 NDSGVDVYYA VTFNGEAISN TTWDLISLHS NKVENHGLVE LDDKPTVVYT ISNFRDYIAE 370 380 390 400 410 420 TLQQNFLLGN SSLNPDPDSL QLINVRGVLR HQTEDLVWNT QSSSLQATPS SILDNTFQAA 430 440 450 460 470 480 WPSADESITS SIPPLDFSSG PPSATGRELW SESPLGDLVS THKLAFPSKM GLSSSPEVLE 490 500 510 520 530 540 VSSLTLHSVT PAVLQTGLPV ASEERTSGSH LVEDGLANVE ESEDFLSIDS LPSSSFTQPV 550 560 570 580 590 600 PKETIPSMED SDVSLTSSPY LTSSIPFGLD SLTSKVKDQL KVSPFLPDAS MEKELIFDGG 610 620 630 640 650 660 LGSGSGQKVD LITWPWSETS SEKSAEPLSK PWLEDDDSLL PAEIEDKKLV LVDKMDSTDQ 670 680 690 700 710 720 ISKHSKYEHD DRSTHFPEEE PLSGPAVPIF ADTAAESASL TLPKHISEVP GVDDYSVTKA 730 740 750 760 770 780 PLILTSVAIS ASTDKSDQAD AILREDMEQI TESSNYEWFD SEVSMVKPDM QTLWTILPES 790 800 810 820 830 840 ERVWTRTSSL EKLSRDILAS TPQSADRLWL SVTQSTKLPP TTISTLLEDE VIMGVQDISL 850 860 870 880 890 900 ELDRIGTDYY QPEQVQEQNG KVGSYVEMST SVHSTEMVSV AWPTEGGDDL SYTQTSGALV 910 920 930 940 950 960 VFFSLRVTNM MFSEDLFNKN SLEYKALEQR FLELLVPYLQ SNLTGFQNLE ILNFRNGSIV 970 980 990 1000 1010 1020 VNSRMKFANS VPPNVNNAVY MILEDFCTTA YNTMNLAIDK YSLDVESGDE ANPCKFQACN 1030 1040 1050 1060 1070 1080 EFSECLVNPW SGEAKCRCFP GYLSVEERPC QSLCDLQPDF CLNDGKCDIM PGHGAICRCR 1090 1100 1110 1120 1130 1140 VGENWWYRGK HCEEFVSEPV IIGITIASVV GLLVIFSAII YFFIRTLQAH HDRSERESPF 1150 1160 1170 1180 1190 1200 SGSSRQPDSL SSIENAVKYN PVYESHRAGC EKYEGPYPQH PFYSSASGDV IGGLSREEIR 1210 1220 1230 1240 QMYESSELSR EEIQERMRVL ELYANDPEFA AFVREQQVEE V

CATM prediction

The sequence of IMPG2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     1100      1110      1120
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 SEAVIIGITIASVVGLLVIFSAIIYFF 7.1 -47.2° 2.2 45.2 -27.2
Prolines* SEPVIIGITIASVVGLLVIFSAIIYFF          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1103, GLY, HA1 A, 1100, VAL, O 2.99Å
B, 1104, ILE, HA A, 1103, GLY, O 3.34Å
A, 1103, GLY, HA1 B, 1100, VAL, O 2.99Å
A, 1104, ILE, HA B, 1103, GLY, O 3.34Å