WD repeat-containing protein 11

UniProt data

UniProt name: WDR11_HUMAN (Q9BZH6)

Gene name: WDR11; Synonyms=BRWD2, KIAA1351, WDR15

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:20887964}. Nucleus {ECO:0000269|PubMed:20887964}. Note=Might be shuttling between the nucleus and the cytoplasm.

Transmembrane domains:

  1. 1127-1147, 21 AA, Helical. {ECO:0000255}.

Sequence: 1224 AA

10 20 30 40 50 60 MLPYTVNFKV SARTLTGALN AHNKAAVDWG WQGLIAYGCH SLVVVIDSIT AQTLQVLEKH 70 80 90 100 110 120 KADVVKVKWA RENYHHNIGS PYCLRLASAD VNGKIIVWDV AAGVAQCEIQ EHAKPIQDVQ 130 140 150 160 170 180 WLWNQDASRD LLLAIHPPNY IVLWNADTGT KLWKKSYADN ILSFSFDPFD PSHLTLLTSE 190 200 210 220 230 240 GIVFISDFSP SKPPSGPGKK VYISSPHSSP AHNKLATATG AKKALNKVKI LITQEKPSAE 250 260 270 280 290 300 FITLNDCLQL AYLPSKRNHM LLLYPREILI LDLEVNQTVG VIAIERTGVP FLQVIPCFQR 310 320 330 340 350 360 DGLFCLHENG CITLRVRRSY NNIFTTSNEE PDPDPVQELT YDLRSQCDAI RVTKTVRPFS 370 380 390 400 410 420 MVCCPVNENA AALVVSDGRV MIWELKSAVC NRNSRNSSSG VSPLYSPVSF CGIPVGVLQN 430 440 450 460 470 480 KLPDLSLDNM IGQSAIAGEE HPRGSILREV HLKFLLTGLL SGLPAPQFAI RMCPPLTTKN 490 500 510 520 530 540 IKMYQPLLAV GTSNGSVLVY HLTSGLLHKE LSIHSCEVKG IEWTSLTSFL SFATSTPNNM 550 560 570 580 590 600 GLVRNELQLV DLPTGRSIAF RGERGNDESA IEMIKVSHLK QYLAVVFRDK PLELWDVRTC 610 620 630 640 650 660 TLLREMSKNF PTITALEWSP SHNLKSLRKK QLATREAMAR QTVVSDTELS IVESSVISLL 670 680 690 700 710 720 QEAESKSELS QNISAREHFV FTDIDGQVYH LTVEGNSVKD SARIPPDGSM GSITCIAWKG 730 740 750 760 770 780 DTLVLGDMDG NLNFWDLKGR VSRGIPTHRS WVRKIRFAPG KGNQKLIAMY NDGAEVWDTK 790 800 810 820 830 840 EVQMVSSLRS GRNVTFRILD VDWCTSDKVI LASDDGCIRV LEMSMKSACF RMDEQELTEP 850 860 870 880 890 900 VWCPYLLVPR ASLALKAFLL HQPWNGQYSL DISHVDYPEN EEIKNLLQEQ LNSLSNDIKK 910 920 930 940 950 960 LLLDPEFTLL QRCLLVSRLY GDESELHFWT VAAHYLHSLS QEKSASTTAP KEAAPRDKLS 970 980 990 1000 1010 1020 NPLDICYDVL CENAYFQKFQ LERVNLQEVK RSTYDHTRKC TDQLLLLGQT DRAVQLLLET 1030 1040 1050 1060 1070 1080 SADNQHYYCD SLKACLVTTV TSSGPSQSTI KLVATNMIAN GKLAEGVQLL CLIDKAADAC 1090 1100 1110 1120 1130 1140 RYLQTYGEWN RAAWLAKVRL NPEECADVLR RWVDHLCSPQ VNQKSKALLV LLSLGCFFSV 1150 1160 1170 1180 1190 1200 AETLHSMRYF DRAALFVEAC LKYGAFEVTE DTEKLITAIY ADYARSLKNL GFKQGAVLFA 1210 1220 SKAGAAGKDL LNELESPKEE PIEE

CATM prediction

The sequence of WDR11_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        1130      1140      1
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 KSKALLVLLSLGCFFSVAETLHSMRYF 6.9 -54.8° 0.9 50.1 -14.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1135, GLY, HA1 A, 1132, LEU, O 3.05Å
B, 1136, CYS, HA A, 1135, GLY, O 3.15Å
B, 1139, SER, HG1 A, 1136, CYS, O 2.46Å
A, 1135, GLY, HA1 B, 1132, LEU, O 3.05Å
A, 1136, CYS, HA B, 1135, GLY, O 3.15Å
A, 1139, SER, HG1 B, 1136, CYS, O 2.46Å