UniProt data
UniProt name: CNTP3_HUMAN (Q9BZ76)
Gene name: CNTNAP3; Synonyms=CASPR3, KIAA1714
Organism: Homo sapiens (Human).
Function:
Subcellular location: Isoform 2: Secreted {ECO:0000305}.
Transmembrane domains:
- 1246-1266, 21 AA, Helical. {ECO:0000255}.
Sequence: 1288 AA
10 20 30 40 50 60
MASVAWAVLK VLLLLPTQTW SPVGAGNPPD CDAPLASALP RSSFSSSSEL SSSHGPGFSR
70 80 90 100 110 120
LNRRDGAGGW TPLVSNKYQW LQIDLGERME VTAVATQGGY GSSDWVTSYL LMFSDGGRNW
130 140 150 160 170 180
KQYRREESIW GFPGNTNADS VVHYRLQPPF EARFLRFLPL AWNPRGRIGM RIEVYGCAYK
190 200 210 220 230 240
SEVVYFDGQS ALLYRLDKKP LKPIRDVISL KFKAMQSNGI LLHREGQHGN HITLELIKGK
250 260 270 280 290 300
LVFFLNSGNA KLPSTIAPVT LTLGSLLDDQ HWHSVLIELL DTQVNFTVDK HTHHFQAKGD
310 320 330 340 350 360
SSYLDLNFEI SFGGIPTPGR SRAFRRKSFH GCLENLYYNG VDVTELAKKH KPQILMMGNV
370 380 390 400 410 420
SFSCPQPQTV PVTFLSSRSY LALPGNSGED KVSVTFQFRT WNRAGHLLFG ELRRGSGSFV
430 440 450 460 470 480
LFLKDGKLKL SLFQPGQSPR NVTAGAGLND GQWHSVSFSA KWSHMNVVVD DDTAVQPLVA
490 500 510 520 530 540
VLIDSGDTYY FGGCLDNSSG SGCKSPLGGF QGCLRLITIG DKAVDPILVQ QGALGSFRDL
550 560 570 580 590 600
QIDSCGITDR CLPSYCEHGG ECSQSWDTFS CDCLGTGYTG ETCHSSLYEQ SCEAHKHRGN
610 620 630 640 650 660
PSGLYYIDAD GSGPLGPFLV YCNMTADAAW TVVQHGGPDA VTLRGAPSGH PRSAVSFAYA
670 680 690 700 710 720
AGAGQLRSAV NLAERCEQRL ALRCGTARRP DSRDGTPLSW WVGRTNETHT SWGGSLPDAQ
730 740 750 760 770 780
KCTCGLEGNC IDSQYYCNCD AGRNEWTSDT IVLSQKEHLP VTQIVMTDAG RPHSEAAYTL
790 800 810 820 830 840
GPLLCRGDQS FWNSASFNTE TSYLHFPAFH GELTADVCFF FKTTVSSGVF MENLGITDFI
850 860 870 880 890 900
RIELRAPTEV TFSFDVGNGP CEVTVQSPTP FNDNQWHHVR AERNVKGASL QVDQLPQKMQ
910 920 930 940 950 960
PAPADGHVRL QLNSQLFIGG TATRQRGFLG CIRSLQLNGV ALDLEERATV TPGVEPGCAG
970 980 990 1000 1010 1020
HCSTYGHLCR NGGRCREKRR GVTCDCAFSA YDGPFCSNEI SAYFATGSSM TYHFQEHYTL
1030 1040 1050 1060 1070 1080
SENSSSLVSS LHRDVTLTRE MITLSFRTTR TPSLLLYVSS FYEEYLSVIL ANNGSLQIRY
1090 1100 1110 1120 1130 1140
KLDRHQNPDA FTFDFKNMAD GQLHQVKINR EEAVVMVEVN QSTKKQVILS SGTEFNAVKS
1150 1160 1170 1180 1190 1200
LILGKVLEAA GADPDTRRAA TSGFTGCLSA VRFGRAAPLK AALRPSGPSR VTVRGHVAPM
1210 1220 1230 1240 1250 1260
ARCAAGAASG SPARELAPRL AGGAGRSGPA DEGEPLVNAD RRDSAVIGGV IAVVIFILLC
1270 1280
ITAIAIRIYQ QRKLRKENES KVSKKEEC
CATM prediction
The sequence of CNTP3_HUMAN returned 2 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 1250 1260 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | DSAVIGGVIAVVIFILLCITAIAIRIY | 6.6 | -47.0° | 2.2 | 45.0 | -19.8 |
| Model 2 | DSAVIGGVIAVVIFILLCITAIAIRIY | 7.0 | -52.0° | 5.2 | 40.0 | -1.5 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 1249, GLY, HA2 | A, 1248, GLY, O | 3.12Å |
| A, 1249, GLY, HA2 | B, 1248, GLY, O | 3.12Å |
