Disintegrin and metalloproteinase domain-containing protein 33

UniProt data

UniProt name: ADA33_HUMAN (Q9BZ11)

Gene name: ADAM33; Synonyms=C20orf153; ORFNames=UNQ873/PRO1891

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 702-722, 21 AA, Helical. {ECO:0000255}.

Sequence: 813 AA

10 20 30 40 50 60 MGWRPRRARG TPLLLLLLLL LLWPVPGAGV LQGHIPGQPV TPHWVLDGQP WRTVSLEEPV 70 80 90 100 110 120 SKPDMGLVAL EAEGQELLLE LEKNHRLLAP GYIETHYGPD GQPVVLAPNH TDHCHYQGRV 130 140 150 160 170 180 RGFPDSWVVL CTCSGMSGLI TLSRNASYYL RPWPPRGSKD FSTHEIFRME QLLTWKGTCG 190 200 210 220 230 240 HRDPGNKAGM TSLPGGPQSR GRREARRTRK YLELYIVADH TLFLTRHRNL NHTKQRLLEV 250 260 270 280 290 300 ANYVDQLLRT LDIQVALTGL EVWTERDRSR VTQDANATLW AFLQWRRGLW AQRPHDSAQL 310 320 330 340 350 360 LTGRAFQGAT VGLAPVEGMC RAESSGGVST DHSELPIGAA ATMAHEIGHS LGLSHDPDGC 370 380 390 400 410 420 CVEAAAESGG CVMAAATGHP FPRVFSACSR RQLRAFFRKG GGACLSNAPD PGLPVPPALC 430 440 450 460 470 480 GNGFVEAGEE CDCGPGQECR DLCCFAHNCS LRPGAQCAHG DCCVRCLLKP AGALCRQAMG 490 500 510 520 530 540 DCDLPEFCTG TSSHCPPDVY LLDGSPCARG SGYCWDGACP TLEQQCQQLW GPGSHPAPEA 550 560 570 580 590 600 CFQVVNSAGD AHGNCGQDSE GHFLPCAGRD ALCGKLQCQG GKPSLLAPHM VPVDSTVHLD 610 620 630 640 650 660 GQEVTCRGAL ALPSAQLDLL GLGLVEPGTQ CGPRMVCQSR RCRKNAFQEL QRCLTACHSH 670 680 690 700 710 720 GVCNSNHNCH CAPGWAPPFC DKPGFGGSMD SGPVQAENHD TFLLAMLLSV LLPLLPGAGL 730 740 750 760 770 780 AWCCYRLPGA HLQRCSWGCR RDPACSGPKD GPHRDHPLGG VHPMELGPTA TGQPWPLDPE 790 800 810 NSHEPSSHPE KPLPAVSPDP QADQVQMPRS CLW

CATM prediction

The sequence of ADA33_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   700       710       720   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 HDTFLLAMLLSVLLALLAGAGLAWCCY 6.7 -45.8° 2.7 47.0 -18.5
Prolines* HDTFLLAMLLSVLLPLLPGAGLAWCCY          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 714, LEU, HA A, 713, ALA, O 2.73Å
B, 717, GLY, HA1 A, 714, LEU, O 2.69Å
B, 718, ALA, HA A, 717, GLY, O 3.31Å
A, 714, LEU, HA B, 713, ALA, O 2.73Å
A, 717, GLY, HA1 B, 714, LEU, O 2.69Å
A, 718, ALA, HA B, 717, GLY, O 3.31Å