Seizure 6-like protein

UniProt data

UniProt name: SE6L1_HUMAN (Q9BYH1)

Gene name: SEZ6L; Synonyms=KIAA0927; ORFNames=UNQ2542/PRO6094

Organism: Homo sapiens (Human).

Function: May contribute to specialized endoplasmic reticulum functions in neurons. {ECO:0000250}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 959-979, 21 AA, Helical. {ECO:0000255}.

Sequence: 1024 AA

10 20 30 40 50 60 MPAARPPAAG LRGISLFLAL LLGSPAAALE RDALPEGDAS PLGPYLLPSG APERGSPGKE 70 80 90 100 110 120 HPEERVVTAP PSSSQSAEVL GELVLDGTAP SAHHDIPALS PLLPEEARPK HALPPKKKLP 130 140 150 160 170 180 SLKQVNSARK QLRPKATSAA TVQRAGSQPA SQGLDLLSSS TEKPGPPGDP DPIVASEEAS 190 200 210 220 230 240 EVPLWLDRKE SAVPTTPAPL QISPFTSQPY VAHTLPQRPE PGEPGPDMAQ EAPQEDTSPM 250 260 270 280 290 300 ALMDKGENEL TGSASEESQE TTTSTIITTT VITTEQAPAL CSVSFSNPEG YIDSSDYPLL 310 320 330 340 350 360 PLNNFLECTY NVTVYTGYGV ELQVKSVNLS DGELLSIRGV DGPTLTVLAN QTLLVEGQVI 370 380 390 400 410 420 RSPTNTISVY FRTFQDDGLG TFQLHYQAFM LSCNFPRRPD SGDVTVMDLH SGGVAHFHCH 430 440 450 460 470 480 LGYELQGAKM LTCINASKPH WSSQEPICSA PCGGAVHNAT IGRVLSPSYP ENTNGSQFCI 490 500 510 520 530 540 WTIEAPEGQK LHLHFERLLL HDKDRMTVHS GQTNKSALLY DSLQTESVPF EGLLSEGNTI 550 560 570 580 590 600 RIEFTSDQAR AASTFNIRFE AFEKGHCYEP YIQNGNFTTS DPTYNIGTIV EFTCDPGHSL 610 620 630 640 650 660 EQGPAIIECI NVRDPYWNDT EPLCRAMCGG ELSAVAGVVL SPNWPEPYVE GEDCIWKIHV 670 680 690 700 710 720 GEEKRIFLDI QFLNLSNSDI LTIYDGDEVM PHILGQYLGN SGPQKLYSST PDLTIQFHSD 730 740 750 760 770 780 PAGLIFGKGQ GFIMNYIEVS RNDSCSDLPE IQNGWKTTSH TELVRGARIT YQCDPGYDIV 790 800 810 820 830 840 GSDTLTCQWD LSWSSDPPFC EKIMYCTDPG EVDHSTRLIS DPVLLVGTTI QYTCNPGFVL 850 860 870 880 890 900 EGSSLLTCYS RETGTPIWTS RLPHCVSEES LACDNPGLPE NGYQILYKRL YLPGESLTFM 910 920 930 940 950 960 CYEGFELMGE VTIRCILGQP SHWNGPLPVC KVNQDSFEHA LEVAEAAAET SLEGGNMALA 970 980 990 1000 1010 1020 IFIPVLIISL LLGGAYIYIT RCRYYSNLRL PLMYSHPYSQ ITVETEFDNP IYETGETREY EVSI

CATM prediction

The sequence of SE6L1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      960       970       980
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 NMALAIFIAVLIISLLLGGAYIYITRC 7.4 -45.9° 3.6 36.8 -12.5
Prolines* NMALAIFIPVLIISLLLGGAYIYITRC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 966, LEU, HA A, 969, SER, OG 3.42Å
B, 970, LEU, HA A, 969, SER, O 3.45Å
B, 973, GLY, HA1 A, 970, LEU, O 3.47Å
A, 966, LEU, HA B, 969, SER, OG 3.42Å
A, 970, LEU, HA B, 969, SER, O 3.45Å
A, 973, GLY, HA1 B, 970, LEU, O 3.47Å