Angiotensin-converting enzyme 2

UniProt data

UniProt name: ACE2_HUMAN (Q9BYF1)

Gene name: ACE2; ORFNames=UNQ868/PRO1885

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV and human coronavirus NL63/HCoV-NL63. {ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:15452268, ECO:0000269|PubMed:15791205, ECO:0000269|PubMed:15897467}.

Subcellular location: Cell membrane; Single-pass type I membrane protein. Cytoplasm {ECO:0000250}. Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250}.

Transmembrane domains:

  1. 741-761, 21 AA, Helical. {ECO:0000255}.

Sequence: 805 AA

10 20 30 40 50 60 MSSSSWLLLS LVAVTAAQST IEEQAKTFLD KFNHEAEDLF YQSSLASWNY NTNITEENVQ 70 80 90 100 110 120 NMNNAGDKWS AFLKEQSTLA QMYPLQEIQN LTVKLQLQAL QQNGSSVLSE DKSKRLNTIL 130 140 150 160 170 180 NTMSTIYSTG KVCNPDNPQE CLLLEPGLNE IMANSLDYNE RLWAWESWRS EVGKQLRPLY 190 200 210 220 230 240 EEYVVLKNEM ARANHYEDYG DYWRGDYEVN GVDGYDYSRG QLIEDVEHTF EEIKPLYEHL 250 260 270 280 290 300 HAYVRAKLMN AYPSYISPIG CLPAHLLGDM WGRFWTNLYS LTVPFGQKPN IDVTDAMVDQ 310 320 330 340 350 360 AWDAQRIFKE AEKFFVSVGL PNMTQGFWEN SMLTDPGNVQ KAVCHPTAWD LGKGDFRILM 370 380 390 400 410 420 CTKVTMDDFL TAHHEMGHIQ YDMAYAAQPF LLRNGANEGF HEAVGEIMSL SAATPKHLKS 430 440 450 460 470 480 IGLLSPDFQE DNETEINFLL KQALTIVGTL PFTYMLEKWR WMVFKGEIPK DQWMKKWWEM 490 500 510 520 530 540 KREIVGVVEP VPHDETYCDP ASLFHVSNDY SFIRYYTRTL YQFQFQEALC QAAKHEGPLH 550 560 570 580 590 600 KCDISNSTEA GQKLFNMLRL GKSEPWTLAL ENVVGAKNMN VRPLLNYFEP LFTWLKDQNK 610 620 630 640 650 660 NSFVGWSTDW SPYADQSIKV RISLKSALGD KAYEWNDNEM YLFRSSVAYA MRQYFLKVKN 670 680 690 700 710 720 QMILFGEEDV RVANLKPRIS FNFFVTAPKN VSDIIPRTEV EKAIRMSRSR INDAFRLNDN 730 740 750 760 770 780 SLEFLGIQPT LGPPNQPPVS IWLIVFGVVM GVIVVGIVIL IFTGIRDRKK KNKARSGENP 790 800 YASIDISKGE NNPGFQNTDD VQTSF

CATM prediction

The sequence of ACE2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    740       750       760  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 AVSIWLIVFGVVMGVIVVGIVILIFTG 6.8 -48.0° 0.8 54.0 -35.2
Prolines* PVSIWLIVFGVVMGVIVVGIVILIFTG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 744, ILE, HA A, 743, LEU, O 3.40Å
B, 747, GLY, HA1 A, 744, ILE, O 2.94Å
B, 748, VAL, HA A, 747, GLY, O 2.95Å
A, 744, ILE, HA B, 743, LEU, O 3.40Å
A, 747, GLY, HA1 B, 744, ILE, O 2.94Å
A, 748, VAL, HA B, 747, GLY, O 2.95Å