Alpha-(1,6)-fucosyltransferase

UniProt data

UniProt name: FUT8_HUMAN (Q9BYC5)

Gene name: FUT8

Organism: Homo sapiens (Human).

Function: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. {ECO:0000269|PubMed:17172260, ECO:0000269|PubMed:9133635}.

Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.

Transmembrane domains:

  1. 10-30, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 575 AA

10 20 30 40 50 60 MRPWTGSWRW IMLILFAWGT LLFYIGGHLV RDNDHPDHSS RELSKILAKL ERLKQQNEDL 70 80 90 100 110 120 RRMAESLRIP EGPIDQGPAI GRVRVLEEQL VKAKEQIENY KKQTRNGLGK DHEILRRRIE 130 140 150 160 170 180 NGAKELWFFL QSELKKLKNL EGNELQRHAD EFLLDLGHHE RSIMTDLYYL SQTDGAGDWR 190 200 210 220 230 240 EKEAKDLTEL VQRRITYLQN PKDCSKAKKL VCNINKGCGY GCQLHHVVYC FMIAYGTQRT 250 260 270 280 290 300 LILESQNWRY ATGGWETVFR PVSETCTDRS GISTGHWSGE VKDKNVQVVE LPIVDSLHPR 310 320 330 340 350 360 PPYLPLAVPE DLADRLVRVH GDPAVWWVSQ FVKYLIRPQP WLEKEIEEAT KKLGFKHPVI 370 380 390 400 410 420 GVHVRRTDKV GTEAAFHPIE EYMVHVEEHF QLLARRMQVD KKRVYLATDD PSLLKEAKTK 430 440 450 460 470 480 YPNYEFISDN SISWSAGLHN RYTENSLRGV ILDIHFLSQA DFLVCTFSSQ VCRVAYEIMQ 490 500 510 520 530 540 TLHPDASANF HSLDDIYYFG GQNAHNQIAI YAHQPRTADE IPMEPGDIIG VAGNHWDGYS 550 560 570 KGVNRKLGRT GLYPSYKVRE KIETVKYPTY PEAEK

CATM prediction

The sequence of FUT8_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     10        20        30  
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 SWRWIMLILFAWGTLLFYIGGHLVRDN 7.2 -52.8° 2.0 44.9 -9.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 24, TYR, HA A, 23, PHE, O 3.46Å
B, 26, GLY, HA1 A, 24, TYR, OH 3.18Å
B, 27, GLY, HA1 A, 24, TYR, O 3.02Å
B, 28, HSE, HA A, 27, GLY, O 3.43Å
A, 24, TYR, HA B, 23, PHE, O 3.46Å
A, 26, GLY, HA1 B, 24, TYR, OH 3.18Å
A, 27, GLY, HA1 B, 24, TYR, O 3.02Å
A, 28, HSE, HA B, 27, GLY, O 3.43Å