UniProt data
UniProt name: MFRP_HUMAN (Q9BY79)
Gene name: MFRP
Organism: Homo sapiens (Human).
Function: May play a role in eye development. {ECO:0000269|PubMed:15976030}.
Subcellular location: Apical cell membrane {ECO:0000250}; Single- pass type II membrane protein {ECO:0000250}.
Transmembrane domains:
- 70-90, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.
Sequence: 579 AA
10 20 30 40 50 60
MKDFSDVILC MEATESSKTE FCNPAFEPES GPPCPPPVFP EDASYSVPAP WHGRRPRGLR
70 80 90 100 110 120
PDCRFSWLCV LLLSSLLLLL LGLLVAIILA QLQAAPPSGA SHSPLPAGGL TTTTTTPTIT
130 140 150 160 170 180
TSQAAGTPKG QQESGVSPSP QSTCGGLLSG PRGFFSSPNY PDPYPPNTHC VWHIQVATDH
190 200 210 220 230 240
AIQLKIEALS IESVASCLFD RLELSPEPEG PLLRVCGRVP PPTLNTNASH LLVVFVSDSS
250 260 270 280 290 300
VEGFGFHAWY QAMAPGRGSC AHDEFRCDQL ICLLPDSVCD GFANCADGSD ETNCSAKFSG
310 320 330 340 350 360
CGGNLTGLQG TFSTPSYLQQ YPHQLLCTWH ISVPAGHSIE LQFHNFSLEA QDECKFDYVE
370 380 390 400 410 420
VYETSSSGAF SLLGRFCGAE PPPHLVSSHH ELAVLFRTDH GISSGGFSAT YLAFNATENP
430 440 450 460 470 480
CGPSELSCQA GGCKGVQWMC DMWRDCTDGS DDNCSGPLFP PPELACEPVQ VEMCLGLSYN
490 500 510 520 530 540
TTAFPNIWVG MITQEEVVEV LSGYKSLTSL PCYQHFRRLL CGLLVPRCTP LGSVLPPCRS
550 560 570
VCQEAEHQCQ SGLALLGTPW PFNCNRLPEA ADLEACAQP
CATM prediction
The sequence of MFRP_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 70 80 90 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | WLCVLLLSSLLLLLLGLLVAIILAQLQ | 7.3 | -48.3° | 0.7 | 53.9 | -20.4 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 82, GLY, HA1 | A, 79, LEU, O | 3.44Å |
| B, 83, LEU, HA | A, 82, GLY, O | 3.50Å |
| A, 82, GLY, HA1 | B, 79, LEU, O | 3.44Å |
| A, 83, LEU, HA | B, 82, GLY, O | 3.50Å |