Toll-like receptor 10

UniProt data

UniProt name: TLR10_HUMAN (Q9BXR5)

Gene name: TLR10; ORFNames=UNQ315/PRO358

Organism: Homo sapiens (Human).

Function: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 577-597, 21 AA, Helical. {ECO:0000255}.

Sequence: 811 AA

10 20 30 40 50 60 MRLIRNIYIF CSIVMTAEGD APELPEEREL MTNCSNMSLR KVPADLTPAT TTLDLSYNLL 70 80 90 100 110 120 FQLQSSDFHS VSKLRVLILC HNRIQQLDLK TFEFNKELRY LDLSNNRLKS VTWYLLAGLR 130 140 150 160 170 180 YLDLSFNDFD TMPICEEAGN MSHLEILGLS GAKIQKSDFQ KIAHLHLNTV FLGFRTLPHY 190 200 210 220 230 240 EEGSLPILNT TKLHIVLPMD TNFWVLLRDG IKTSKILEMT NIDGKSQFVS YEMQRNLSLE 250 260 270 280 290 300 NAKTSVLLLN KVDLLWDDLF LILQFVWHTS VEHFQIRNVT FGGKAYLDHN SFDYSNTVMR 310 320 330 340 350 360 TIKLEHVHFR VFYIQQDKIY LLLTKMDIEN LTISNAQMPH MLFPNYPTKF QYLNFANNIL 370 380 390 400 410 420 TDELFKRTIQ LPHLKTLILN GNKLETLSLV SCFANNTPLE HLDLSQNLLQ HKNDENCSWP 430 440 450 460 470 480 ETVVNMNLSY NKLSDSVFRC LPKSIQILDL NNNQIQTVPK ETIHLMALRE LNIAFNFLTD 490 500 510 520 530 540 LPGCSHFSRL SVLNIEMNFI LSPSLDFVQS CQEVKTLNAG RNPFRCTCEL KNFIQLETYS 550 560 570 580 590 600 EVMMVGWSDS YTCEYPLNLR GTRLKDVHLH ELSCNTALLI VTIVVIMLVL GLAVAFCCLH 610 620 630 640 650 660 FDLPWYLRML GQCTQTWHRV RKTTQEQLKR NVRFHAFISY SEHDSLWVKN ELIPNLEKED 670 680 690 700 710 720 GSILICLYES YFDPGKSISE NIVSFIEKSY KSIFVLSPNF VQNEWCHYEF YFAHHNLFHE 730 740 750 760 770 780 NSDHIILILL EPIPFYCIPT RYHKLKALLE KKAYLEWPKD RRKCGLFWAN LRAAINVNVL 790 800 810 ATREMYELQT FTELNEESRG STISLMRTDC L

CATM prediction

The sequence of TLR10_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        580       590       6
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 CNTALLIVTIVVIMLVLGLAVAFCCLH 7.0 -52.1° 1.4 56.9 -6.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 591, GLY, HA1 A, 588, LEU, O 3.21Å
B, 592, LEU, HA A, 591, GLY, O 3.46Å
A, 591, GLY, HA1 B, 588, LEU, O 3.21Å
A, 592, LEU, HA B, 591, GLY, O 3.46Å