Junctional adhesion molecule C

UniProt data

UniProt name: JAM3_HUMAN (Q9BX67)

Gene name: JAM3; ORFNames=UNQ859/PRO1868

Organism: Homo sapiens (Human).

Function: Participates in cell-cell adhesion. It is a counter- receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis. {ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:20592283}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, desmosome {ECO:0000269|PubMed:15194813}. Secreted, extracellular space {ECO:0000269|PubMed:20592283}. Note=In epithelial cells, it is expressed at desmosomes but not at tight junctions (PubMed:15194813). Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts (PubMed:15994945).

Transmembrane domains:

  1. 242-262, 21 AA, Helical. {ECO:0000255}.

Sequence: 310 AA

10 20 30 40 50 60 MALRRPPRLR LCARLPDFFL LLLFRGCLIG AVNLKSSNRT PVVQEFESVE LSCIITDSQT 70 80 90 100 110 120 SDPRIEWKKI QDEQTTYVFF DNKIQGDLAG RAEILGKTSL KIWNVTRRDS ALYRCEVVAR 130 140 150 160 170 180 NDRKEIDEIV IELTVQVKPV TPVCRVPKAV PVGKMATLHC QESEGHPRPH YSWYRNDVPL 190 200 210 220 230 240 PTDSRANPRF RNSSFHLNSE TGTLVFTAVH KDDSGQYYCI ASNDAGSARC EEQEMEVYDL 250 260 270 280 290 300 NIGGIIGGVL VVLAVLALIT LGICCAYRRG YFINNKQDGE SYKNPGKPDG VNYIRTDEEG DFRHKSSFVI

CATM prediction

The sequence of JAM3_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   240       250       260   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 DLNIGGIIGGVLVVLAVLALITLGICC 6.5 -45.1° 4.0 39.0 -19.5
Model 2 DLNIGGIIGGVLVVLAVLALITLGICC 6.6 -48.0° 0.8 54.0 -15.1
Model 3 DLNIGGIIGGVLVVLAVLALITLGICC 6.8 -28.0° 6.0 47.0 -9.0
Model 4 DLNIGGIIGGVLVVLAVLALITLGICC 6.4 -55.0° 4.9 53.3 -8.7
Model 5 DLNIGGIIGGVLVVLAVLALITLGICC 7.0 -40.0° 5.1 44.0 -6.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 244, GLY, HA2 A, 243, GLY, O 2.51Å
B, 247, GLY, HA1 A, 244, GLY, O 2.70Å
A, 244, GLY, HA2 B, 243, GLY, O 2.51Å
A, 247, GLY, HA1 B, 244, GLY, O 2.70Å