Tapasin-related protein

UniProt data

UniProt name: TPSNR_HUMAN (Q9BX59)

Gene name: TAPBPL

Organism: Homo sapiens (Human).

Function: Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. {ECO:0000269|PubMed:23401559}.

Subcellular location: Cell membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Microsome membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Golgi apparatus membrane {ECO:0000269|PubMed:23401559}; Single-pass type I membrane protein {ECO:0000269|PubMed:23401559}. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573).

Transmembrane domains:

  1. 406-426, 21 AA, Helical. {ECO:0000255}.

Sequence: 468 AA

10 20 30 40 50 60 MGTQEGWCLL LCLALSGAAE TKPHPAEGQW RAVDVVLDCF LAKDGAHRGA LASSEDRARA 70 80 90 100 110 120 SLVLKQVPVL DDGSLEDFTD FQGGTLAQDD PPIIFEASVD LVQIPQAEAL LHADCSGKEV 130 140 150 160 170 180 TCEISRYFLQ MTETTVKTAA WFMANMQVSG GGPSISLVMK TPRVTKNEAL WHPTLNLPLS 190 200 210 220 230 240 PQGTVRTAVE FQVMTQTQSL SFLLGSSASL DCGFSMAPGL DLISVEWRLQ HKGRGQLVYS 250 260 270 280 290 300 WTAGQGQAVR KGATLEPAQL GMARDASLTL PGLTIQDEGT YICQITTSLY RAQQIIQLNI 310 320 330 340 350 360 QASPKVRLSL ANEALLPTLI CDIAGYYPLD VVVTWTREEL GGSPAQVSGA SFSSLRQSVA 370 380 390 400 410 420 GTYSISSSLT AEPGSAGATY TCQVTHISLE EPLGASTQVV PPERRTALGV IFASSLFLLA 430 440 450 460 LMFLGLQRRQ APTGLGLLQA ERWETTSCAD TQSSHLHEDR TARVSQPS

CATM prediction

The sequence of TPSNR_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         410       420       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 ERRTALGVIFASSLFLLALMFLGLQRR 6.8 -46.1° 2.7 47.0 -25.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 409, GLY, HA1 A, 406, THR, O 2.77Å
B, 410, VAL, HA A, 409, GLY, O 3.37Å
A, 409, GLY, HA1 B, 406, THR, O 2.77Å
A, 410, VAL, HA B, 409, GLY, O 3.37Å