Brother of CDO

UniProt data

UniProt name: BOC_HUMAN (Q9BWV1)

Gene name: BOC; ORFNames=UNQ604/PRO1190

Organism: Homo sapiens (Human).

Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.

Subcellular location: Cell membrane {ECO:0000269|PubMed:12634428}; Single-pass type I membrane protein {ECO:0000269|PubMed:12634428}. Note=Enriched at sites of cell-cell contact.

Transmembrane domains:

  1. 856-876, 21 AA, Helical. {ECO:0000255}.

Sequence: 1114 AA

10 20 30 40 50 60 MLRGTMTAWR GMRPEVTLAC LLLATAGCFA DLNEVPQVTV QPASTVQKPG GTVILGCVVE 70 80 90 100 110 120 PPRMNVTWRL NGKELNGSDD ALGVLITHGT LVITALNNHT VGRYQCVARM PAGAVASVPA 130 140 150 160 170 180 TVTLANLQDF KLDVQHVIEV DEGNTAVIAC HLPESHPKAQ VRYSVKQEWL EASRGNYLIM 190 200 210 220 230 240 PSGNLQIVNA SQEDEGMYKC AAYNPVTQEV KTSGSSDRLR VRRSTAEAAR IIYPPEAQTI 250 260 270 280 290 300 IVTKGQSLIL ECVASGIPPP RVTWAKDGSS VTGYNKTRFL LSNLLIDTTS EEDSGTYRCM 310 320 330 340 350 360 ADNGVGQPGA AVILYNVQVF EPPEVTMELS QLVIPWGQSA KLTCEVRGNP PPSVLWLRNA 370 380 390 400 410 420 VPLISSQRLR LSRRALRVLS MGPEDEGVYQ CMAENEVGSA HAVVQLRTSR PSITPRLWQD 430 440 450 460 470 480 AELATGTPPV SPSKLGNPEQ MLRGQPALPR PPTSVGPASP QCPGEKGQGA PAEAPIILSS 490 500 510 520 530 540 PRTSKTDSYE LVWRPRHEGS GRAPILYYVV KHRKVTNSSD DWTISGIPAN QHRLTLTRLD 550 560 570 580 590 600 PGSLYEVEMA AYNCAGEGQT AMVTFRTGRR PKPEIMASKE QQIQRDDPGA SPQSSSQPDH 610 620 630 640 650 660 GRLSPPEAPD RPTISTASET SVYVTWIPRG NGGFPIQSFR VEYKKLKKVG DWILATSAIP 670 680 690 700 710 720 PSRLSVEITG LEKGTSYKFR VRALNMLGES EPSAPSRPYV VSGYSGRVYE RPVAGPYITF 730 740 750 760 770 780 TDAVNETTIM LKWMYIPASN NNTPIHGFYI YYRPTDSDND SDYKKDMVEG DKYWHSISHL 790 800 810 820 830 840 QPETSYDIKM QCFNEGGESE FSNVMICETK ARKSSGQPGR LPPPTLAPPQ PPLPETIERP 850 860 870 880 890 900 VGTGAMVARS SDLPYLIVGV VLGSIVLIIV TFIPFCLWRA WSKQKHTTDL GFPRSALPPS 910 920 930 940 950 960 CPYTMVPLGG LPGHQASGQP YLSGISGRAC ANGIHMNRGC PSAAVGYPGM KPQQHCPGEL 970 980 990 1000 1010 1020 QQQSDTSSLL RQTHLGNGYD PQSHQITRGP KSSPDEGSFL YTLPDDSTHQ LLQPHHDCCQ 1030 1040 1050 1060 1070 1080 RQEQPAAVGQ SGVRRAPDSP VLEAVWDPPF HSGPPCCLGL VPVEEVDSPD SCQVSGGDWC 1090 1100 1110 PQHPVGAYVG QEPGMQLSPG PLVRVSFETP PLTI

CATM prediction

The sequence of BOC_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         860       870       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 LAYLIVGVVLGSIVLIIVTFIAFCLWR 6.8 -29.8° 3.4 52.9 -40.9
Model 2 LAYLIVGVVLGSIVLIIVTFIAFCLWR 6.8 -52.0° 1.4 57.0 -29.1
Model 3 LAYLIVGVVLGSIVLIIVTFIAFCLWR 7.4 -54.1° 3.6 49.1 -11.3
Prolines* LPYLIVGVVLGSIVLIIVTFIPFCLWR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 859, GLY, HA1 A, 856, LEU, O 3.13Å
B, 860, VAL, HA A, 859, GLY, O 3.43Å
A, 859, GLY, HA1 B, 856, LEU, O 3.13Å
A, 860, VAL, HA B, 859, GLY, O 3.43Å